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001     164030
005     20250414105535.0
024 7 _ |a 10.1007/s11011-022-00973-y
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024 7 _ |a 0885-7490
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037 _ _ |a DZNE-2022-00693
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082 _ _ |a 610
100 1 _ |a Liu, Chunxin
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245 _ _ |a Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study.
260 _ _ |a Dordrecht [u.a.]
|c 2022
|b Springer Science + Business Media B.V
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520 _ _ |a To determine the relationship between basal metabolic rate (BMR) and multiple sclerosis (MS) susceptibility, we analyzed genome-wide association study (GWAS) summary statistics data from the International Multiple Sclerosis Genetics Consortium on a total of 115,803 participants of European descent, including 47,429 patients with MS and 68,374 controls. We selected 378 independent genetic variants strongly associated with BMR in a GWAS involving 454,874 participants as instrumental variables to examine a potential causal relationship between BMR and MS. A genetically predicted higher BMR was associated with a greater risk of MS (odds ratio [OR]: 1.283 per one standard deviation increase in BMR, 95% confidence interval [CI]: 1.108-1.486, P = 0.001). Moreover, we used the lasso method to eliminate heterogeneity (Q statistic = 384.58, P = 0.370). There was no pleiotropy in our study and no bias was found in the sensitivity analysis using the leave-one-out test. We provide novel evidence that a higher BMR is an independent causal risk factor in the development of MS. Further work is warranted to elucidate the potential mechanisms.
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650 _ 7 |a Basal metabolic rate
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650 _ 7 |a Genome-wide association study
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650 _ 7 |a Mendelian randomization
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650 _ 7 |a Multiple sclerosis
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650 _ 2 |a Basal Metabolism: genetics
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Mendelian Randomization Analysis
|2 MeSH
650 _ 2 |a Multiple Sclerosis: epidemiology
|2 MeSH
650 _ 2 |a Multiple Sclerosis: genetics
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide: genetics
|2 MeSH
700 1 _ |a Lu, Yaxin
|b 1
700 1 _ |a Chen, Jingjing
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700 1 _ |a Qiu, Wei
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700 1 _ |a Zhan, Yiqiang
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700 1 _ |a Liu, Zifeng
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773 _ _ |a 10.1007/s11011-022-00973-y
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|t Metabolic brain disease
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856 4 _ |u https://pub.dzne.de/record/164030/files/DZNE-2022-00693_Restricted.pdf
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