000164035 001__ 164035
000164035 005__ 20240222115045.0
000164035 0247_ $$2doi$$a10.1016/j.cell.2021.12.040
000164035 0247_ $$2pmid$$apmid:35032429
000164035 0247_ $$2pmc$$apmc:PMC8712270
000164035 0247_ $$2ISSN$$a0092-8674
000164035 0247_ $$2ISSN$$a1097-4172
000164035 0247_ $$2altmetric$$aaltmetric:119917627
000164035 037__ $$aDZNE-2022-00698
000164035 041__ $$aEnglish
000164035 082__ $$a610
000164035 1001_ $$aGeorg, Philipp$$b0
000164035 245__ $$aComplement activation induces excessive T cell cytotoxicity in severe COVID-19.
000164035 260__ $$aNew York, NY$$bElsevier$$c2022
000164035 3367_ $$2DRIVER$$aarticle
000164035 3367_ $$2DataCite$$aOutput Types/Journal article
000164035 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1708514579_22068
000164035 3367_ $$2BibTeX$$aARTICLE
000164035 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000164035 3367_ $$00$$2EndNote$$aJournal Article
000164035 520__ $$aSevere COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated CD16+ T cells with increased cytotoxic functions in severe COVID-19. CD16 expression enabled immune-complex-mediated, T cell receptor-independent degranulation and cytotoxicity not found in other diseases. CD16+ T cells from COVID-19 patients promoted microvascular endothelial cell injury and release of neutrophil and monocyte chemoattractants. CD16+ T cell clones persisted beyond acute disease maintaining their cytotoxic phenotype. Increased generation of C3a in severe COVID-19 induced activated CD16+ cytotoxic T cells. Proportions of activated CD16+ T cells and plasma levels of complement proteins upstream of C3a were associated with fatal outcome of COVID-19, supporting a pathological role of exacerbated cytotoxicity and complement activation in COVID-19.
000164035 536__ $$0G:(DE-HGF)POF4-354$$a354 - Disease Prevention and Healthy Aging (POF4-354)$$cPOF4-354$$fPOF IV$$x0
000164035 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000164035 650_7 $$2Other$$aCOVID-19
000164035 650_7 $$2Other$$aT cells
000164035 650_7 $$2Other$$acomplement
000164035 650_7 $$2Other$$acytotoxicity
000164035 650_7 $$2Other$$aimmunopathology
000164035 650_7 $$2NLM Chemicals$$aChemotactic Factors
000164035 650_7 $$2NLM Chemicals$$aProteome
000164035 650_7 $$2NLM Chemicals$$aReceptors, IgG
000164035 650_2 $$2MeSH$$aAdult
000164035 650_2 $$2MeSH$$aAged
000164035 650_2 $$2MeSH$$aAged, 80 and over
000164035 650_2 $$2MeSH$$aCOVID-19: immunology
000164035 650_2 $$2MeSH$$aCOVID-19: pathology
000164035 650_2 $$2MeSH$$aCOVID-19: virology
000164035 650_2 $$2MeSH$$aChemotactic Factors: metabolism
000164035 650_2 $$2MeSH$$aComplement Activation
000164035 650_2 $$2MeSH$$aCytotoxicity, Immunologic
000164035 650_2 $$2MeSH$$aEndothelial Cells: virology
000164035 650_2 $$2MeSH$$aFemale
000164035 650_2 $$2MeSH$$aHumans
000164035 650_2 $$2MeSH$$aLymphocyte Activation
000164035 650_2 $$2MeSH$$aMale
000164035 650_2 $$2MeSH$$aMicrovessels: virology
000164035 650_2 $$2MeSH$$aMiddle Aged
000164035 650_2 $$2MeSH$$aMonocytes: metabolism
000164035 650_2 $$2MeSH$$aNeutrophils: metabolism
000164035 650_2 $$2MeSH$$aProteome
000164035 650_2 $$2MeSH$$aReceptors, IgG: metabolism
000164035 650_2 $$2MeSH$$aSARS-CoV-2: immunology
000164035 650_2 $$2MeSH$$aSingle-Cell Analysis
000164035 650_2 $$2MeSH$$aT-Lymphocytes, Cytotoxic: immunology
000164035 650_2 $$2MeSH$$aTranscriptome
000164035 650_2 $$2MeSH$$aYoung Adult
000164035 7001_ $$aAstaburuaga-García, Rosario$$b1
000164035 7001_ $$0P:(DE-2719)9001512$$aBonaguro, Lorenzo$$b2$$udzne
000164035 7001_ $$aBrumhard, Sophia$$b3
000164035 7001_ $$aMichalick, Laura$$b4
000164035 7001_ $$aLippert, Lena J$$b5
000164035 7001_ $$aKostevc, Tomislav$$b6
000164035 7001_ $$aGäbel, Christiane$$b7
000164035 7001_ $$aSchneider, Maria$$b8
000164035 7001_ $$aStreitz, Mathias$$b9
000164035 7001_ $$aDemichev, Vadim$$b10
000164035 7001_ $$0P:(DE-2719)2812074$$aGemünd, Ioanna Dafni$$b11$$udzne
000164035 7001_ $$aBarone, Matthias$$b12
000164035 7001_ $$aTober-Lau, Pinkus$$b13
000164035 7001_ $$aHelbig, Elisa T$$b14
000164035 7001_ $$aHillus, David$$b15
000164035 7001_ $$aPetrov, Lev$$b16
000164035 7001_ $$aStein, Julia$$b17
000164035 7001_ $$aDey, Hannah-Philine$$b18
000164035 7001_ $$aPaclik, Daniela$$b19
000164035 7001_ $$aIwert, Christina$$b20
000164035 7001_ $$aMülleder, Michael$$b21
000164035 7001_ $$aAulakh, Simran Kaur$$b22
000164035 7001_ $$aDjudjaj, Sonja$$b23
000164035 7001_ $$aBülow, Roman D$$b24
000164035 7001_ $$aMei, Henrik E$$b25
000164035 7001_ $$aSchulz, Axel R$$b26
000164035 7001_ $$aThiel, Andreas$$b27
000164035 7001_ $$aHippenstiel, Stefan$$b28
000164035 7001_ $$aSaliba, Antoine-Emmanuel$$b29
000164035 7001_ $$aEils, Roland$$b30
000164035 7001_ $$aLehmann, Irina$$b31
000164035 7001_ $$aMall, Marcus A$$b32
000164035 7001_ $$aStricker, Sebastian$$b33
000164035 7001_ $$aRöhmel, Jobst$$b34
000164035 7001_ $$0P:(DE-2719)9001090$$aCorman, Victor$$b35$$udzne
000164035 7001_ $$aBeule, Dieter$$b36
000164035 7001_ $$aWyler, Emanuel$$b37
000164035 7001_ $$aLandthaler, Markus$$b38
000164035 7001_ $$aObermayer, Benedikt$$b39
000164035 7001_ $$avon Stillfried, Saskia$$b40
000164035 7001_ $$aBoor, Peter$$b41
000164035 7001_ $$aDemir, Münevver$$b42
000164035 7001_ $$aWesselmann, Hans$$b43
000164035 7001_ $$aSuttorp, Norbert$$b44
000164035 7001_ $$aUhrig, Alexander$$b45
000164035 7001_ $$aMüller-Redetzky, Holger$$b46
000164035 7001_ $$aNattermann, Jacob$$b47
000164035 7001_ $$aKuebler, Wolfgang M$$b48
000164035 7001_ $$aMeisel, Christian$$b49
000164035 7001_ $$aRalser, Markus$$b50
000164035 7001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim L$$b51$$udzne
000164035 7001_ $$0P:(DE-2719)2812913$$aAschenbrenner, Anna C$$b52$$udzne
000164035 7001_ $$aThibeault, Charlotte$$b53
000164035 7001_ $$aKurth, Florian$$b54
000164035 7001_ $$aSander, Leif E$$b55
000164035 7001_ $$aBlüthgen, Nils$$b56
000164035 7001_ $$aSawitzki, Birgit$$b57
000164035 7001_ $$aGroup, PA-COVID-19 Study$$b58$$eCollaboration Author
000164035 773__ $$0PERI:(DE-600)2001951-8$$a10.1016/j.cell.2021.12.040$$gVol. 185, no. 3, p. 493 - 512.e25$$n3$$p493 - 512.e25$$tCell$$v185$$x0092-8674$$y2022
000164035 7870_ $$0DZNE-2022-01801$$aGeorg, Philipp et.al.$$dZenodo, 2021$$iRelatedTo$$r$$tComplement activation induces excessive T cell cytotoxicity in severe COVID-19: Analysis of single cell data cohort 1 (Berlin).
000164035 8564_ $$uhttps://pub.dzne.de/record/164035/files/DZNE-2022-00698.pdf$$yOpenAccess
000164035 8564_ $$uhttps://pub.dzne.de/record/164035/files/DZNE-2022-00698.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000164035 909CO $$ooai:pub.dzne.de:164035$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000164035 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001512$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000164035 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2812074$$aExternal Institute$$b11$$kExtern
000164035 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001090$$aExternal Institute$$b35$$kExtern
000164035 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811660$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b51$$kDZNE
000164035 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812913$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b52$$kDZNE
000164035 9131_ $$0G:(DE-HGF)POF4-354$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Prevention and Healthy Aging$$x0
000164035 9141_ $$y2022
000164035 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-03
000164035 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000164035 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCELL : 2021$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-03
000164035 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)9960$$2StatID$$aIF >= 60$$bCELL : 2021$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-09
000164035 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-03
000164035 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000164035 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2022-11-09$$wger
000164035 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-09
000164035 9201_ $$0I:(DE-2719)1013031$$kSchultze - PRECISE$$lPlatform for Single Cell Genomics and Epigenomics$$x0
000164035 9201_ $$0I:(DE-2719)5000031$$kR&D PRECISE$$lPlatform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn$$x1
000164035 980__ $$ajournal
000164035 980__ $$aVDB
000164035 980__ $$aUNRESTRICTED
000164035 980__ $$aI:(DE-2719)1013031
000164035 980__ $$aI:(DE-2719)5000031
000164035 9801_ $$aFullTexts