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@ARTICLE{Georg:164035,
      author       = {Georg, Philipp and Astaburuaga-García, Rosario and
                      Bonaguro, Lorenzo and Brumhard, Sophia and Michalick, Laura
                      and Lippert, Lena J and Kostevc, Tomislav and Gäbel,
                      Christiane and Schneider, Maria and Streitz, Mathias and
                      Demichev, Vadim and Gemünd, Ioanna Dafni and Barone,
                      Matthias and Tober-Lau, Pinkus and Helbig, Elisa T and
                      Hillus, David and Petrov, Lev and Stein, Julia and Dey,
                      Hannah-Philine and Paclik, Daniela and Iwert, Christina and
                      Mülleder, Michael and Aulakh, Simran Kaur and Djudjaj,
                      Sonja and Bülow, Roman D and Mei, Henrik E and Schulz, Axel
                      R and Thiel, Andreas and Hippenstiel, Stefan and Saliba,
                      Antoine-Emmanuel and Eils, Roland and Lehmann, Irina and
                      Mall, Marcus A and Stricker, Sebastian and Röhmel, Jobst
                      and Corman, Victor and Beule, Dieter and Wyler, Emanuel and
                      Landthaler, Markus and Obermayer, Benedikt and von
                      Stillfried, Saskia and Boor, Peter and Demir, Münevver and
                      Wesselmann, Hans and Suttorp, Norbert and Uhrig, Alexander
                      and Müller-Redetzky, Holger and Nattermann, Jacob and
                      Kuebler, Wolfgang M and Meisel, Christian and Ralser, Markus
                      and Schultze, Joachim L and Aschenbrenner, Anna C and
                      Thibeault, Charlotte and Kurth, Florian and Sander, Leif E
                      and Blüthgen, Nils and Sawitzki, Birgit},
      collaboration = {Group, PA-COVID-19 Study},
      title        = {{C}omplement activation induces excessive {T} cell
                      cytotoxicity in severe {COVID}-19.},
      journal      = {Cell},
      volume       = {185},
      number       = {3},
      issn         = {0092-8674},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2022-00698},
      pages        = {493 - 512.e25},
      year         = {2022},
      abstract     = {Severe COVID-19 is linked to both dysfunctional immune
                      response and unrestrained immunopathology, and it remains
                      unclear whether T cells contribute to disease pathology.
                      Here, we combined single-cell transcriptomics and
                      single-cell proteomics with mechanistic studies to assess
                      pathogenic T cell functions and inducing signals. We
                      identified highly activated CD16+ T cells with increased
                      cytotoxic functions in severe COVID-19. CD16 expression
                      enabled immune-complex-mediated, T cell receptor-independent
                      degranulation and cytotoxicity not found in other diseases.
                      CD16+ T cells from COVID-19 patients promoted microvascular
                      endothelial cell injury and release of neutrophil and
                      monocyte chemoattractants. CD16+ T cell clones persisted
                      beyond acute disease maintaining their cytotoxic phenotype.
                      Increased generation of C3a in severe COVID-19 induced
                      activated CD16+ cytotoxic T cells. Proportions of activated
                      CD16+ T cells and plasma levels of complement proteins
                      upstream of C3a were associated with fatal outcome of
                      COVID-19, supporting a pathological role of exacerbated
                      cytotoxicity and complement activation in COVID-19.},
      keywords     = {Adult / Aged / Aged, 80 and over / COVID-19: immunology /
                      COVID-19: pathology / COVID-19: virology / Chemotactic
                      Factors: metabolism / Complement Activation / Cytotoxicity,
                      Immunologic / Endothelial Cells: virology / Female / Humans
                      / Lymphocyte Activation / Male / Microvessels: virology /
                      Middle Aged / Monocytes: metabolism / Neutrophils:
                      metabolism / Proteome / Receptors, IgG: metabolism /
                      SARS-CoV-2: immunology / Single-Cell Analysis /
                      T-Lymphocytes, Cytotoxic: immunology / Transcriptome / Young
                      Adult / COVID-19 (Other) / T cells (Other) / complement
                      (Other) / cytotoxicity (Other) / immunopathology (Other) /
                      Chemotactic Factors (NLM Chemicals) / Proteome (NLM
                      Chemicals) / Receptors, IgG (NLM Chemicals)},
      cin          = {Schultze - PRECISE / $R\&D$ PRECISE},
      ddc          = {610},
      cid          = {I:(DE-2719)1013031 / I:(DE-2719)5000031},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354)},
      pid          = {G:(DE-HGF)POF4-354},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35032429},
      pmc          = {pmc:PMC8712270},
      doi          = {10.1016/j.cell.2021.12.040},
      url          = {https://pub.dzne.de/record/164035},
}