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| 001 | 164035 | ||
| 005 | 20240222115045.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cell.2021.12.040 |2 doi |
| 024 | 7 | _ | |a pmid:35032429 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC8712270 |2 pmc |
| 024 | 7 | _ | |a 0092-8674 |2 ISSN |
| 024 | 7 | _ | |a 1097-4172 |2 ISSN |
| 024 | 7 | _ | |a altmetric:119917627 |2 altmetric |
| 037 | _ | _ | |a DZNE-2022-00698 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Georg, Philipp |b 0 |
| 245 | _ | _ | |a Complement activation induces excessive T cell cytotoxicity in severe COVID-19. |
| 260 | _ | _ | |a New York, NY |c 2022 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1708514579_22068 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, we combined single-cell transcriptomics and single-cell proteomics with mechanistic studies to assess pathogenic T cell functions and inducing signals. We identified highly activated CD16+ T cells with increased cytotoxic functions in severe COVID-19. CD16 expression enabled immune-complex-mediated, T cell receptor-independent degranulation and cytotoxicity not found in other diseases. CD16+ T cells from COVID-19 patients promoted microvascular endothelial cell injury and release of neutrophil and monocyte chemoattractants. CD16+ T cell clones persisted beyond acute disease maintaining their cytotoxic phenotype. Increased generation of C3a in severe COVID-19 induced activated CD16+ cytotoxic T cells. Proportions of activated CD16+ T cells and plasma levels of complement proteins upstream of C3a were associated with fatal outcome of COVID-19, supporting a pathological role of exacerbated cytotoxicity and complement activation in COVID-19. |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a COVID-19 |2 Other |
| 650 | _ | 7 | |a T cells |2 Other |
| 650 | _ | 7 | |a complement |2 Other |
| 650 | _ | 7 | |a cytotoxicity |2 Other |
| 650 | _ | 7 | |a immunopathology |2 Other |
| 650 | _ | 7 | |a Chemotactic Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Proteome |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, IgG |2 NLM Chemicals |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 650 | _ | 2 | |a COVID-19: immunology |2 MeSH |
| 650 | _ | 2 | |a COVID-19: pathology |2 MeSH |
| 650 | _ | 2 | |a COVID-19: virology |2 MeSH |
| 650 | _ | 2 | |a Chemotactic Factors: metabolism |2 MeSH |
| 650 | _ | 2 | |a Complement Activation |2 MeSH |
| 650 | _ | 2 | |a Cytotoxicity, Immunologic |2 MeSH |
| 650 | _ | 2 | |a Endothelial Cells: virology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Lymphocyte Activation |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Microvessels: virology |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Monocytes: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neutrophils: metabolism |2 MeSH |
| 650 | _ | 2 | |a Proteome |2 MeSH |
| 650 | _ | 2 | |a Receptors, IgG: metabolism |2 MeSH |
| 650 | _ | 2 | |a SARS-CoV-2: immunology |2 MeSH |
| 650 | _ | 2 | |a Single-Cell Analysis |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes, Cytotoxic: immunology |2 MeSH |
| 650 | _ | 2 | |a Transcriptome |2 MeSH |
| 650 | _ | 2 | |a Young Adult |2 MeSH |
| 700 | 1 | _ | |a Astaburuaga-García, Rosario |b 1 |
| 700 | 1 | _ | |a Bonaguro, Lorenzo |0 P:(DE-2719)9001512 |b 2 |u dzne |
| 700 | 1 | _ | |a Brumhard, Sophia |b 3 |
| 700 | 1 | _ | |a Michalick, Laura |b 4 |
| 700 | 1 | _ | |a Lippert, Lena J |b 5 |
| 700 | 1 | _ | |a Kostevc, Tomislav |b 6 |
| 700 | 1 | _ | |a Gäbel, Christiane |b 7 |
| 700 | 1 | _ | |a Schneider, Maria |b 8 |
| 700 | 1 | _ | |a Streitz, Mathias |b 9 |
| 700 | 1 | _ | |a Demichev, Vadim |b 10 |
| 700 | 1 | _ | |a Gemünd, Ioanna Dafni |0 P:(DE-2719)2812074 |b 11 |u dzne |
| 700 | 1 | _ | |a Barone, Matthias |b 12 |
| 700 | 1 | _ | |a Tober-Lau, Pinkus |b 13 |
| 700 | 1 | _ | |a Helbig, Elisa T |b 14 |
| 700 | 1 | _ | |a Hillus, David |b 15 |
| 700 | 1 | _ | |a Petrov, Lev |b 16 |
| 700 | 1 | _ | |a Stein, Julia |b 17 |
| 700 | 1 | _ | |a Dey, Hannah-Philine |b 18 |
| 700 | 1 | _ | |a Paclik, Daniela |b 19 |
| 700 | 1 | _ | |a Iwert, Christina |b 20 |
| 700 | 1 | _ | |a Mülleder, Michael |b 21 |
| 700 | 1 | _ | |a Aulakh, Simran Kaur |b 22 |
| 700 | 1 | _ | |a Djudjaj, Sonja |b 23 |
| 700 | 1 | _ | |a Bülow, Roman D |b 24 |
| 700 | 1 | _ | |a Mei, Henrik E |b 25 |
| 700 | 1 | _ | |a Schulz, Axel R |b 26 |
| 700 | 1 | _ | |a Thiel, Andreas |b 27 |
| 700 | 1 | _ | |a Hippenstiel, Stefan |b 28 |
| 700 | 1 | _ | |a Saliba, Antoine-Emmanuel |b 29 |
| 700 | 1 | _ | |a Eils, Roland |b 30 |
| 700 | 1 | _ | |a Lehmann, Irina |b 31 |
| 700 | 1 | _ | |a Mall, Marcus A |b 32 |
| 700 | 1 | _ | |a Stricker, Sebastian |b 33 |
| 700 | 1 | _ | |a Röhmel, Jobst |b 34 |
| 700 | 1 | _ | |a Corman, Victor |0 P:(DE-2719)9001090 |b 35 |u dzne |
| 700 | 1 | _ | |a Beule, Dieter |b 36 |
| 700 | 1 | _ | |a Wyler, Emanuel |b 37 |
| 700 | 1 | _ | |a Landthaler, Markus |b 38 |
| 700 | 1 | _ | |a Obermayer, Benedikt |b 39 |
| 700 | 1 | _ | |a von Stillfried, Saskia |b 40 |
| 700 | 1 | _ | |a Boor, Peter |b 41 |
| 700 | 1 | _ | |a Demir, Münevver |b 42 |
| 700 | 1 | _ | |a Wesselmann, Hans |b 43 |
| 700 | 1 | _ | |a Suttorp, Norbert |b 44 |
| 700 | 1 | _ | |a Uhrig, Alexander |b 45 |
| 700 | 1 | _ | |a Müller-Redetzky, Holger |b 46 |
| 700 | 1 | _ | |a Nattermann, Jacob |b 47 |
| 700 | 1 | _ | |a Kuebler, Wolfgang M |b 48 |
| 700 | 1 | _ | |a Meisel, Christian |b 49 |
| 700 | 1 | _ | |a Ralser, Markus |b 50 |
| 700 | 1 | _ | |a Schultze, Joachim L |0 P:(DE-2719)2811660 |b 51 |u dzne |
| 700 | 1 | _ | |a Aschenbrenner, Anna C |0 P:(DE-2719)2812913 |b 52 |u dzne |
| 700 | 1 | _ | |a Thibeault, Charlotte |b 53 |
| 700 | 1 | _ | |a Kurth, Florian |b 54 |
| 700 | 1 | _ | |a Sander, Leif E |b 55 |
| 700 | 1 | _ | |a Blüthgen, Nils |b 56 |
| 700 | 1 | _ | |a Sawitzki, Birgit |b 57 |
| 700 | 1 | _ | |a Group, PA-COVID-19 Study |b 58 |e Collaboration Author |
| 773 | _ | _ | |a 10.1016/j.cell.2021.12.040 |g Vol. 185, no. 3, p. 493 - 512.e25 |0 PERI:(DE-600)2001951-8 |n 3 |p 493 - 512.e25 |t Cell |v 185 |y 2022 |x 0092-8674 |
| 787 | 0 | _ | |a Georg, Philipp et.al. |d Zenodo, 2021 |i RelatedTo |0 DZNE-2022-01801 |r |t Complement activation induces excessive T cell cytotoxicity in severe COVID-19: Analysis of single cell data cohort 1 (Berlin). |
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