TY  - JOUR
AU  - Kopczak, Anna
AU  - Schindler, Andreas
AU  - Sepp, Dominik
AU  - Bayer-Karpinska, Anna
AU  - Malik, Rainer
AU  - Koch, Mia L
AU  - Zeller, Julia
AU  - Strecker, Christoph
AU  - Janowitz, Daniel
AU  - Wollenweber, Frank A
AU  - Hempel, Johann-Martin
AU  - Boeckh-Behrens, Tobias
AU  - Cyran, Clemens C
AU  - Helck, Andreas
AU  - Harloff, Andreas
AU  - Ziemann, Ulf
AU  - Poli, Sven
AU  - Poppert, Holger
AU  - Saam, Tobias
AU  - Dichgans, Martin
TI  - Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA.
JO  - Journal of the American College of Cardiology
VL  - 79
IS  - 22
SN  - 0735-1097
CY  - New York, NY
PB  - American College of Cardiology
M1  - DZNE-2022-00701
SP  - 2189-2199
PY  - 2022
N1  - (CC BY-NC-ND)
AB  - Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.The purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic attack (TIA).The CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter study prospectively recruited patients with ischemic stroke restricted to the territory of a single carotid artery. Complicated (AHA-lesion type VI) CAP were defined by multisequence, contrast-enhanced carotid magnetic resonance imaging obtained within 10 days from stroke onset. Recurrent events were assessed after 3, 12, 24, and 36 months. The primary outcome was recurrent ischemic stroke or TIA.Among 196 patients enrolled, 104 patients had cryptogenic stroke and nonstenosing CAP. During a mean follow-up of 30 months, recurrent ischemic stroke or TIA occurred in 21 patients. Recurrent events were significantly more frequent in patients with icCAP than in patients without icCAP, both in the overall cohort (incidence rate [3-year interval]: 9.50 vs 3.61 per 100 patient-years; P = 0.025, log-rank test) and in patients with cryptogenic stroke (10.92 vs 1.82 per 100 patient-years; P = 0.003). The results were driven by ipsilateral events. A ruptured fibrous cap (HR: 4.91; 95
KW  - Carotid Arteries: pathology
KW  - Carotid Stenosis: complications
KW  - Carotid Stenosis: diagnostic imaging
KW  - Carotid Stenosis: epidemiology
KW  - Humans
KW  - Ischemic Attack, Transient: epidemiology
KW  - Ischemic Attack, Transient: etiology
KW  - Ischemic Stroke
KW  - Plaque, Atherosclerotic: complications
KW  - Plaque, Atherosclerotic: diagnostic imaging
KW  - Plaque, Atherosclerotic: pathology
KW  - Risk Factors
KW  - Stroke: diagnosis
KW  - Stroke: epidemiology
KW  - Stroke: etiology
KW  - MRI (Other)
KW  - carotid artery (Other)
KW  - carotid plaque (Other)
KW  - intraplaque hemorrhage (Other)
KW  - ischemic stroke (Other)
KW  - stroke recurrence (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35523659
DO  - DOI:10.1016/j.jacc.2022.03.376
UR  - https://pub.dzne.de/record/164038
ER  -