% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Kopczak:164038,
      author       = {Kopczak, Anna and Schindler, Andreas and Sepp, Dominik and
                      Bayer-Karpinska, Anna and Malik, Rainer and Koch, Mia L and
                      Zeller, Julia and Strecker, Christoph and Janowitz, Daniel
                      and Wollenweber, Frank A and Hempel, Johann-Martin and
                      Boeckh-Behrens, Tobias and Cyran, Clemens C and Helck,
                      Andreas and Harloff, Andreas and Ziemann, Ulf and Poli, Sven
                      and Poppert, Holger and Saam, Tobias and Dichgans, Martin},
      title        = {{C}omplicated {C}arotid {A}rtery {P}laques and {R}isk of
                      {R}ecurrent {I}schemic {S}troke or {TIA}.},
      journal      = {Journal of the American College of Cardiology},
      volume       = {79},
      number       = {22},
      issn         = {0735-1097},
      address      = {New York, NY},
      publisher    = {American College of Cardiology},
      reportid     = {DZNE-2022-00701},
      pages        = {2189-2199},
      year         = {2022},
      note         = {(CC BY-NC-ND)},
      abstract     = {Complicated nonstenosing carotid artery plaques (CAPs) are
                      an under-recognized cause of stroke.The purpose of this
                      study was to determine whether complicated CAP ipsilateral
                      to acute ischemic anterior circulation stroke (icCAP) are
                      associated with recurrent ischemic stroke or transient
                      ischemic attack (TIA).The CAPIAS (Carotid Plaque Imaging in
                      Acute Stroke) multicenter study prospectively recruited
                      patients with ischemic stroke restricted to the territory of
                      a single carotid artery. Complicated (AHA-lesion type VI)
                      CAP were defined by multisequence, contrast-enhanced carotid
                      magnetic resonance imaging obtained within 10 days from
                      stroke onset. Recurrent events were assessed after 3, 12,
                      24, and 36 months. The primary outcome was recurrent
                      ischemic stroke or TIA.Among 196 patients enrolled, 104
                      patients had cryptogenic stroke and nonstenosing CAP. During
                      a mean follow-up of 30 months, recurrent ischemic stroke or
                      TIA occurred in 21 patients. Recurrent events were
                      significantly more frequent in patients with icCAP than in
                      patients without icCAP, both in the overall cohort
                      (incidence rate [3-year interval]: 9.50 vs 3.61 per 100
                      patient-years; P = 0.025, log-rank test) and in patients
                      with cryptogenic stroke (10.92 vs 1.82 per 100
                      patient-years; P = 0.003). The results were driven by
                      ipsilateral events. A ruptured fibrous cap (HR: 4.91; $95\%$
                      CI: 1.31-18.45; P = 0.018) and intraplaque hemorrhage (HR:
                      4.37; $95\%$ CI: 1.20-15.97; P = 0.026) were associated with
                      a significantly increased risk of recurrent events in
                      patients with cryptogenic stroke.Complicated CAP ipsilateral
                      to acute ischemic anterior circulation stroke are associated
                      with an increased risk of recurrent ischemic stroke or TIA.
                      Carotid plaque imaging identifies high-risk patients who
                      might be suited for inclusion into future secondary
                      prevention trials. (Carotid Plaque Imaging in Acute Stroke
                      [CAPIAS]; NCT01284933).},
      keywords     = {Carotid Arteries: pathology / Carotid Stenosis:
                      complications / Carotid Stenosis: diagnostic imaging /
                      Carotid Stenosis: epidemiology / Humans / Ischemic Attack,
                      Transient: epidemiology / Ischemic Attack, Transient:
                      etiology / Ischemic Stroke / Plaque, Atherosclerotic:
                      complications / Plaque, Atherosclerotic: diagnostic imaging
                      / Plaque, Atherosclerotic: pathology / Risk Factors /
                      Stroke: diagnosis / Stroke: epidemiology / Stroke: etiology
                      / MRI (Other) / carotid artery (Other) / carotid plaque
                      (Other) / intraplaque hemorrhage (Other) / ischemic stroke
                      (Other) / stroke recurrence (Other)},
      cin          = {AG Dichgans},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35523659},
      doi          = {10.1016/j.jacc.2022.03.376},
      url          = {https://pub.dzne.de/record/164038},
}