TY  - JOUR
AU  - Feldmann, Lucia K
AU  - Lofredi, Roxanne
AU  - Neumann, Wolf-Julian
AU  - Al-Fatly, Bassam
AU  - Roediger, Jan
AU  - Bahners, Bahne H
AU  - Nikolov, Petyo
AU  - Denison, Timothy
AU  - Saryyeva, Assel
AU  - Krauss, Joachim K
AU  - Faust, Katharina
AU  - Florin, Esther
AU  - Schnitzler, Alfons
AU  - Schneider, Gerd-Helge
AU  - Kühn, Andrea A
TI  - Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.
JO  - npj Parkinson's Disease
VL  - 8
IS  - 1
SN  - 2373-8057
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - DZNE-2022-00721
SP  - 44
PY  - 2022
AB  - Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson's patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p < 0.001), stimulation amplitude for beta suppression (p < 0.001). Here, we characterize beta-band modulation as a chronic biomarker for motor performance. Our investigations support the use of electrophysiology in therapy optimization, providing evidence for the use of biomarker analysis for clinical aDBS.
LB  - PUB:(DE-HGF)16
C6  - pmid:35440571
C2  - pmc:PMC9018912
DO  - DOI:10.1038/s41531-022-00301-2
UR  - https://pub.dzne.de/record/164058
ER  -