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@ARTICLE{Feldmann:164058,
      author       = {Feldmann, Lucia K and Lofredi, Roxanne and Neumann,
                      Wolf-Julian and Al-Fatly, Bassam and Roediger, Jan and
                      Bahners, Bahne H and Nikolov, Petyo and Denison, Timothy and
                      Saryyeva, Assel and Krauss, Joachim K and Faust, Katharina
                      and Florin, Esther and Schnitzler, Alfons and Schneider,
                      Gerd-Helge and Kühn, Andrea A},
      title        = {{T}oward therapeutic electrophysiology: beta-band
                      suppression as a biomarker in chronic local field potential
                      recordings.},
      journal      = {npj Parkinson's Disease},
      volume       = {8},
      number       = {1},
      issn         = {2373-8057},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2022-00721},
      pages        = {44},
      year         = {2022},
      abstract     = {Adaptive deep brain stimulation (aDBS) is a promising
                      concept for feedback-based neurostimulation, with the
                      potential of clinical implementation with the
                      sensing-enabled Percept neurostimulator. We aim to
                      characterize chronic electrophysiological activity during
                      stimulation and to validate beta-band activity as a
                      biomarker for bradykinesia. Subthalamic activity was
                      recorded during stepwise stimulation amplitude increase OFF
                      medication in 10 Parkinson's patients during rest and finger
                      tapping. Offline analysis of wavelet-transformed beta-band
                      activity and assessment of inter-variable relationships in
                      linear mixed effects models were implemented. There was a
                      stepwise suppression of low-beta activity with increasing
                      stimulation intensity (p = 0.002). Low-beta power was
                      negatively correlated with movement speed and predictive for
                      velocity improvements (p < 0.001), stimulation amplitude for
                      beta suppression (p < 0.001). Here, we characterize
                      beta-band modulation as a chronic biomarker for motor
                      performance. Our investigations support the use of
                      electrophysiology in therapy optimization, providing
                      evidence for the use of biomarker analysis for clinical
                      aDBS.},
      cin          = {AG Endres},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35440571},
      pmc          = {pmc:PMC9018912},
      doi          = {10.1038/s41531-022-00301-2},
      url          = {https://pub.dzne.de/record/164058},
}