TY  - JOUR
AU  - Kleineidam, Luca
AU  - Stark, Melina
AU  - Riedel-Heller, Steffi G
AU  - Pabst, Alexander
AU  - Schmiedek, Florian
AU  - Streit, Fabian
AU  - Rietschel, Marcella
AU  - Klinger-König, Johanna
AU  - Grabe, Hans J
AU  - Erhardt, Angelika
AU  - Gelbrich, Götz
AU  - Schmidt, Börge
AU  - Berger, Klaus
AU  - Wagner, Michael
AU  - Peters, Annette
AU  - Fischer, Beate
AU  - Leitzmann, Michael
AU  - Greiser, Karin Halina
AU  - Kaaks, Rudolph
AU  - Michels, Karin B
AU  - Franzke, Claus-Werner
AU  - Brenner, Hermann
AU  - Holleczek, Bernd
AU  - Schramm, Sara
AU  - Jöckel, Karl-Heinz
AU  - Minnerup, Heike
AU  - Karch, André
AU  - Feinkohl, Insa
AU  - Pischon, Tobias
AU  - Krist, Lilian
AU  - Willich, Stefan N
AU  - Schulze, Matthias B
AU  - Castell, Stefanie
AU  - Hassenstein, Max J
AU  - Obi, Nadia
AU  - Becher, Heiko
AU  - Günther, Kathrin
AU  - Rach, Stefan
AU  - Lieb, Wolfgang
AU  - Schipf, Sabine
AU  - Meinke-Franze, Claudia
TI  - The assessment of cognitive function in the German National Cohort (NAKO) - Associations of demographics and psychiatric symptoms with cognitive test performance.
JO  - The world journal of biological psychiatry
VL  - 24
IS  - 10
SN  - 1562-2975
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - DZNE-2022-00727
SP  - 909 - 923
PY  - 2023
AB  - To describe the cognitive test battery of the German National Cohort (NAKO), a population-based mega cohort of 205,000 randomly selected participants, and to examine associations with demographic variables and selected psychiatric and neurological conditions.Initial data from 96,401 participants providing data on the cognitive performance measured by a brief cognitive test battery (12-word list recall task, semantic fluency, Stroop test, digit span backwards) was examined. Test results were summarised in cognitive domain scores using exploratory and confirmatory factor analyses. Associations with sociodemographic and psychiatric factors were analysed using linear regression and generalised additive models.Cognitive test results were best represented by two domain scores reflecting memory and executive functions. Lower cognitive functions were associated with increasing age and male sex. Higher education and absence of childhood trauma were associated with better cognitive function. Moderate to severe levels of anxiety and depression, and a history of stroke, were related to lower cognitive function with a stronger effect on executive function as compared to memory. Some associations with cognition differed by German language proficiency.The NAKO cognitive test battery and the derived cognitive domain scores for memory and executive function are sensitive measures of cognition.
KW  - Humans
KW  - Male
KW  - Cognition
KW  - Executive Function
KW  - Neuropsychological Tests
KW  - Language
KW  - Demography
KW  - Cognition (Other)
KW  - German National Cohort (Other)
KW  - NAKO (Other)
KW  - cognitive ageing (Other)
KW  - confirmatory factor analysis (Other)
KW  - depression (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35175181
DO  - DOI:10.1080/15622975.2021.2011408
UR  - https://pub.dzne.de/record/164064
ER  -