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@ARTICLE{Kleineidam:164064,
author = {Kleineidam, Luca and Stark, Melina and Riedel-Heller,
Steffi G and Pabst, Alexander and Schmiedek, Florian and
Streit, Fabian and Rietschel, Marcella and Klinger-König,
Johanna and Grabe, Hans J and Erhardt, Angelika and
Gelbrich, Götz and Schmidt, Börge and Berger, Klaus and
Wagner, Michael and Peters, Annette and Fischer, Beate and
Leitzmann, Michael and Greiser, Karin Halina and Kaaks,
Rudolph and Michels, Karin B and Franzke, Claus-Werner and
Brenner, Hermann and Holleczek, Bernd and Schramm, Sara and
Jöckel, Karl-Heinz and Minnerup, Heike and Karch, André
and Feinkohl, Insa and Pischon, Tobias and Krist, Lilian and
Willich, Stefan N and Schulze, Matthias B and Castell,
Stefanie and Hassenstein, Max J and Obi, Nadia and Becher,
Heiko and Günther, Kathrin and Rach, Stefan and Lieb,
Wolfgang and Schipf, Sabine and Meinke-Franze, Claudia},
collaboration = {Investigators, NAKO},
title = {{T}he assessment of cognitive function in the {G}erman
{N}ational {C}ohort ({NAKO}) - {A}ssociations of
demographics and psychiatric symptoms with cognitive test
performance.},
journal = {The world journal of biological psychiatry},
volume = {24},
number = {10},
issn = {1562-2975},
address = {Abingdon},
publisher = {Taylor $\&$ Francis Group},
reportid = {DZNE-2022-00727},
pages = {909 - 923},
year = {2023},
abstract = {To describe the cognitive test battery of the German
National Cohort (NAKO), a population-based mega cohort of
205,000 randomly selected participants, and to examine
associations with demographic variables and selected
psychiatric and neurological conditions.Initial data from
96,401 participants providing data on the cognitive
performance measured by a brief cognitive test battery
(12-word list recall task, semantic fluency, Stroop test,
digit span backwards) was examined. Test results were
summarised in cognitive domain scores using exploratory and
confirmatory factor analyses. Associations with
sociodemographic and psychiatric factors were analysed using
linear regression and generalised additive models.Cognitive
test results were best represented by two domain scores
reflecting memory and executive functions. Lower cognitive
functions were associated with increasing age and male sex.
Higher education and absence of childhood trauma were
associated with better cognitive function. Moderate to
severe levels of anxiety and depression, and a history of
stroke, were related to lower cognitive function with a
stronger effect on executive function as compared to memory.
Some associations with cognition differed by German language
proficiency.The NAKO cognitive test battery and the derived
cognitive domain scores for memory and executive function
are sensitive measures of cognition.},
keywords = {Humans / Male / Cognition / Executive Function /
Neuropsychological Tests / Language / Demography / Cognition
(Other) / German National Cohort (Other) / NAKO (Other) /
cognitive ageing (Other) / confirmatory factor analysis
(Other) / depression (Other)},
cin = {AG Wagner / AG Grabe / AG Hoffmann},
ddc = {610},
cid = {I:(DE-2719)1011201 / I:(DE-2719)5000001 /
I:(DE-2719)1510600},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:35175181},
doi = {10.1080/15622975.2021.2011408},
url = {https://pub.dzne.de/record/164064},
}