000164068 001__ 164068
000164068 005__ 20250127111059.0
000164068 0247_ $$2doi$$a10.1080/15622975.2022.2058084
000164068 0247_ $$2pmid$$apmid:35332851
000164068 0247_ $$2ISSN$$a1562-2975
000164068 0247_ $$2ISSN$$a1814-1412
000164068 037__ $$aDZNE-2022-00731
000164068 041__ $$aEnglish
000164068 082__ $$a610
000164068 1001_ $$aBonnekoh, Linda M$$b0
000164068 245__ $$aLong-term cortisol stress response in depression and comorbid anxiety is linked with reduced N-acetylaspartate in the anterior cingulate cortex.
000164068 260__ $$aAbingdon$$bTaylor & Francis Group$$c2023
000164068 3367_ $$2DRIVER$$aarticle
000164068 3367_ $$2DataCite$$aOutput Types/Journal article
000164068 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1678873948_1563
000164068 3367_ $$2BibTeX$$aARTICLE
000164068 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000164068 3367_ $$00$$2EndNote$$aJournal Article
000164068 520__ $$a Major Depression (MDD) and anxiety disorders are stress-related disorders that share pathophysiological mechanisms. There is evidence for alterations of glutamate-glutamine, N-acetylaspartate (NAA) and GABA in the anterior cingulate cortex (ACC), a stress-sensitive region affected by hypothalamic-pituitary-adrenal axis (HPA). The aim was to investigate metabolic alterations in the ACC and whether hair cortisol, current stress or early life adversity predict them.We investigated 22 patients with MDD and comorbid anxiety disorder and 23 healthy controls. Proton magnetic resonance spectroscopy was performed with voxels placed in pregenual (pg) and dorsal (d) ACC in 3 T. Analysis of hair cortisol was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).The N-acetylaspartate/Creatin ratio (NAA/Cr) was reduced in patients in both pgACC (p = .040) and dACC (p = .016). A significant interactive effect of diagnosis and cortisol on both pg-NAA/Cr (F = 5.00, p = .033) and d-NAA/Cr (F = 7.86, p = .009) was detected, whereby in controls cortisol was positively correlated with d-NAA/Cr (r = 0.61, p = .004).Our results suggest a relationship between NAA metabolism in ACC and HPA axis activity as represented by long-term cortisol output.
000164068 536__ $$0G:(DE-HGF)POF4-899$$a899 - ohne Topic (POF4-899)$$cPOF4-899$$fPOF IV$$x0
000164068 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000164068 650_7 $$2Other$$aanterior
000164068 650_7 $$2Other$$aanxiety disorders
000164068 650_7 $$2Other$$adepression
000164068 650_7 $$2Other$$amagnet resonance spectroscopy
000164068 650_7 $$2Other$$astress
000164068 650_2 $$2MeSH$$aHumans
000164068 650_2 $$2MeSH$$aHydrocortisone: metabolism
000164068 650_2 $$2MeSH$$aHypothalamo-Hypophyseal System: metabolism
000164068 650_2 $$2MeSH$$aGyrus Cinguli: metabolism
000164068 650_2 $$2MeSH$$aChromatography, Liquid
000164068 650_2 $$2MeSH$$aDepression
000164068 650_2 $$2MeSH$$aPituitary-Adrenal System: metabolism
000164068 650_2 $$2MeSH$$aTandem Mass Spectrometry
000164068 650_2 $$2MeSH$$aDepressive Disorder, Major: metabolism
000164068 650_2 $$2MeSH$$aAnxiety
000164068 650_2 $$2MeSH$$aAspartic Acid: metabolism
000164068 650_2 $$2MeSH$$aAnxiety Disorders
000164068 7001_ $$aSeidenbecher, Stephanie$$b1
000164068 7001_ $$aKnigge, Katrin$$b2
000164068 7001_ $$aHünecke, Anne-Kathrin$$b3
000164068 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline D$$b4$$udzne
000164068 7001_ $$aTempelmann, Claus$$b5
000164068 7001_ $$aKanowski, Martin$$b6
000164068 7001_ $$aKaufmann, Jörn$$b7
000164068 7001_ $$aMeyer-Lotz, Gabriela$$b8
000164068 7001_ $$aSchlaaff, Konstantin$$b9
000164068 7001_ $$aDobrowolny, Henrik$$b10
000164068 7001_ $$aTozzi, Leonardo$$b11
000164068 7001_ $$aGescher, Dorothee M$$b12
000164068 7001_ $$aSteiner, Johann$$b13
000164068 7001_ $$aKirschbaum, Clemens$$b14
000164068 7001_ $$0P:(DE-2719)2812075$$aFrodl, Thomas$$b15$$udzne
000164068 773__ $$0PERI:(DE-600)2170223-8$$a10.1080/15622975.2022.2058084$$gp. 1 - 35$$n1$$p34-45$$tThe world journal of biological psychiatry$$v24$$x1562-2975$$y2023
000164068 909CO $$ooai:pub.dzne.de:164068$$pVDB
000164068 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000443$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000164068 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)2812075$$aExternal Institute$$b15$$kExtern
000164068 9131_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000164068 9141_ $$y2023
000164068 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-02
000164068 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-02
000164068 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-08-26$$wger
000164068 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bWORLD J BIOL PSYCHIA : 2022$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-26
000164068 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-26
000164068 9201_ $$0I:(DE-2719)1340007$$kCore Technical Staff$$lCore KAP (Kooperationseinheit Angewandte Präventionsforschung)$$x0
000164068 980__ $$ajournal
000164068 980__ $$aVDB
000164068 980__ $$aI:(DE-2719)1340007
000164068 980__ $$aUNRESTRICTED