TY  - JOUR
AU  - Bonnekoh, Linda M
AU  - Seidenbecher, Stephanie
AU  - Knigge, Katrin
AU  - Hünecke, Anne-Kathrin
AU  - Metzger, Coraline D
AU  - Tempelmann, Claus
AU  - Kanowski, Martin
AU  - Kaufmann, Jörn
AU  - Meyer-Lotz, Gabriela
AU  - Schlaaff, Konstantin
AU  - Dobrowolny, Henrik
AU  - Tozzi, Leonardo
AU  - Gescher, Dorothee M
AU  - Steiner, Johann
AU  - Kirschbaum, Clemens
AU  - Frodl, Thomas
TI  - Long-term cortisol stress response in depression and comorbid anxiety is linked with reduced N-acetylaspartate in the anterior cingulate cortex.
JO  - The world journal of biological psychiatry
VL  - 24
IS  - 1
SN  - 1562-2975
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - DZNE-2022-00731
SP  - 34-45
PY  - 2023
AB  -  Major Depression (MDD) and anxiety disorders are stress-related disorders that share pathophysiological mechanisms. There is evidence for alterations of glutamate-glutamine, N-acetylaspartate (NAA) and GABA in the anterior cingulate cortex (ACC), a stress-sensitive region affected by hypothalamic-pituitary-adrenal axis (HPA). The aim was to investigate metabolic alterations in the ACC and whether hair cortisol, current stress or early life adversity predict them.We investigated 22 patients with MDD and comorbid anxiety disorder and 23 healthy controls. Proton magnetic resonance spectroscopy was performed with voxels placed in pregenual (pg) and dorsal (d) ACC in 3 T. Analysis of hair cortisol was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).The N-acetylaspartate/Creatin ratio (NAA/Cr) was reduced in patients in both pgACC (p = .040) and dACC (p = .016). A significant interactive effect of diagnosis and cortisol on both pg-NAA/Cr (F = 5.00, p = .033) and d-NAA/Cr (F = 7.86, p = .009) was detected, whereby in controls cortisol was positively correlated with d-NAA/Cr (r = 0.61, p = .004).Our results suggest a relationship between NAA metabolism in ACC and HPA axis activity as represented by long-term cortisol output.
KW  - Humans
KW  - Hydrocortisone: metabolism
KW  - Hypothalamo-Hypophyseal System: metabolism
KW  - Gyrus Cinguli: metabolism
KW  - Chromatography, Liquid
KW  - Depression
KW  - Pituitary-Adrenal System: metabolism
KW  - Tandem Mass Spectrometry
KW  - Depressive Disorder, Major: metabolism
KW  - Anxiety
KW  - Aspartic Acid: metabolism
KW  - Anxiety Disorders
KW  - anterior (Other)
KW  - anxiety disorders (Other)
KW  - depression (Other)
KW  - magnet resonance spectroscopy (Other)
KW  - stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35332851
DO  - DOI:10.1080/15622975.2022.2058084
UR  - https://pub.dzne.de/record/164068
ER  -