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@ARTICLE{Shafiei:164077,
      author       = {Shafiei, Golia and Bazinet, Vincent and Dadar, Mahsa and
                      Manera, Ana L and Collins, D Louis and Dagher, Alain and
                      Borroni, Barbara and Sanchez-Valle, Raquel and Moreno,
                      Fermin and Laforce, Robert and Graff, Caroline and Synofzik,
                      Matthis and Galimberti, Daniela and Rowe, James B and
                      Masellis, Mario and Tartaglia, Maria Carmela and Finger,
                      Elizabeth and Vandenberghe, Rik and de Mendonça, Alexandre
                      and Tagliavini, Fabrizio and Santana, Isabel and Butler,
                      Chris and Gerhard, Alex and Danek, Adrian and Levin,
                      Johannes and Otto, Markus and Sorbi, Sandro and Jiskoot,
                      Lize C and Seelaar, Harro and van Swieten, John C and
                      Rohrer, Jonathan D and Misic, Bratislav and Ducharme, Simon},
      collaboration = {Initiative, Frontotemporal Lobar Degeneration Neuroimaging
                      and Initiative, GENetic Frontotemporal dementia},
      title        = {{N}etwork structure and transcriptomic vulnerability shape
                      atrophy in frontotemporal dementia},
      journal      = {Brain},
      volume       = {146},
      number       = {1},
      issn         = {0006-8950},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2022-00740},
      pages        = {321-336},
      year         = {2022},
      abstract     = {Connections among brain regions allow pathological
                      perturbations to spread from a single source region to
                      multiple regions. Patterns of neurodegeneration in multiple
                      diseases, including behavioural variant of frontotemporal
                      dementia (bvFTD), resemble the large-scale functional
                      systems, but how bvFTD-related atrophy patterns relate to
                      structural network organization remains unknown. Here we
                      investigate whether neurodegeneration patterns in sporadic
                      and genetic bvFTD are conditioned by connectome
                      architecture. Regional atrophy patterns were estimated in
                      both genetic bvFTD (75 patients, 247 controls) and sporadic
                      bvFTD (70 patients, 123 controls). First, we identified
                      distributed atrophy patterns in bvFTD, mainly targeting
                      areas associated with the limbic intrinsic network and
                      insular cytoarchitectonic class. Regional atrophy was
                      significantly correlated with atrophy of structurally- and
                      functionally-connected neighbours, demonstrating that
                      network structure shapes atrophy patterns. The anterior
                      insula was identified as the predominant group epicentre of
                      brain atrophy using data-driven and simulation-based
                      methods, with some secondary regions in frontal ventromedial
                      and antero-medial temporal areas. We found that FTD-related
                      genes, namely C9orf72 and TARDBP, confer local
                      transcriptomic vulnerability to the disease, modulating the
                      propagation of pathology through the connectome.
                      Collectively, our results demonstrate that atrophy patterns
                      in sporadic and genetic bvFTD are jointly shaped by global
                      connectome architecture and local transcriptomic
                      vulnerability, providing an explanation as to how
                      heterogenous pathological entities can lead to the same
                      clinical syndrome.},
      keywords     = {Humans / Frontotemporal Dementia: diagnostic imaging /
                      Frontotemporal Dementia: genetics / Frontotemporal Dementia:
                      pathology / Transcriptome / Brain: pathology / Pick Disease
                      of the Brain: pathology / Atrophy: pathology / Connectome /
                      Magnetic Resonance Imaging / Neuropsychological Tests /
                      connectome (Other) / disease epicentre (Other) /
                      frontotemporal dementia (Other) / gene expression (Other) /
                      network spreading (Other)},
      cin          = {AG Gasser 1 / Clinical Dementia Research München},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000 / I:(DE-2719)1111016},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9825569},
      pubmed       = {pmid:35188955},
      doi          = {10.1093/brain/awac069},
      url          = {https://pub.dzne.de/record/164077},
}