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@ARTICLE{Luecken:164110,
author = {Luecken, Malte D and Zaragosi, Laure-Emmanuelle and
Madissoon, Elo and Sikkema, Lisa and Firsova, Alexandra B
and De Domenico, Elena and Kümmerle, Louis and Saglam, Adem
and Berg, Marijn and Gay, Aurore C A and Schniering, Janine
and Mayr, Christoph H and Abalo, Xesús M and Larsson,
Ludvig and Sountoulidis, Alexandros and Teichmann, Sarah and
van Eunen, Karen and Koppelman, Gerard H and Saeb-Parsy,
Kourosh and Leroy, Sylvie and Powell, Pippa and Sarkans,
Ugis and Timens, Wim and Lundeberg, Joakim and van den
Berge, Maarten and Nilsson, Mats and Horváth, Peter and
Denning, Jessica and Papatheodorou, Irene and Schultze,
Joachim and Schiller, Herbert B and Barbry, Pascal and
Petoukhov, Ilya and Misharin, Alexander V and Adcock, Ian
and von Papen, Michael and Theis, Fabian J and Samakovlis,
Christos and Meyer, Kerstin B and Nawijn, Martijn C},
title = {{T}he discov{AIR} project: a roadmap towards the {H}uman
{L}ung {C}ell {A}tlas.},
journal = {The European respiratory journal},
volume = {60},
number = {2},
issn = {0903-1936},
address = {Lausanne},
publisher = {ERS},
reportid = {DZNE-2022-00773},
pages = {2102057},
year = {2022},
note = {CC BY-NC: https://creativecommons.org/licenses/by-nc/4.0/},
abstract = {The Human Cell Atlas (HCA) consortium aims to establish an
atlas of all organs in the healthy human body at single-cell
resolution to increase our understanding of basic biological
processes that govern development, physiology and anatomy,
and to accelerate diagnosis and treatment of disease. The
lung biological network of the HCA aims to generate the
Human Lung Cell Atlas as a reference for the cellular
repertoire, molecular cell states and phenotypes, and the
cell-cell interactions that characterise normal lung
homeostasis in healthy lung tissue. Such a reference atlas
of the healthy human lung will facilitate mapping the
changes in the cellular landscape in disease. The discovAIR
project is one of six pilot actions for the HCA funded by
the European Commission in the context of the H2020
framework program. DiscovAIR aims to establish the first
draft of an integrated Human Lung Cell Atlas, combining
single-cell transcriptional and epigenetic profiling with
spatially resolving techniques on matched tissue samples, as
well as including a number of chronic and infectious
diseases of the lung. The integrated Lung Cell Atlas will be
available as a resource for the wider respiratory community,
including basic and translational scientists, clinical
medicine, and the private sector, as well as for patients
with lung disease and the interested lay public. We
anticipate that the Lung Cell Atlas will be the founding
stone for a more detailed understanding of the pathogenesis
of lung diseases, guiding the design of novel diagnostics
and preventive or curative interventions.},
subtyp = {Review Article},
keywords = {Humans / Lung / Lung Diseases / Proteomics / Thorax},
cin = {PRECISE / AG Schultze},
ddc = {610},
cid = {I:(DE-2719)1013031 / I:(DE-2719)1013038},
pnm = {354 - Disease Prevention and Healthy Aging (POF4-354)},
pid = {G:(DE-HGF)POF4-354},
experiment = {EXP:(DE-2719)PRECISE-20190321},
typ = {PUB:(DE-HGF)16},
pmc = {pmc:PMC9386332},
pubmed = {pmid:35086829},
doi = {10.1183/13993003.02057-2021},
url = {https://pub.dzne.de/record/164110},
}