000164114 001__ 164114
000164114 005__ 20240826165947.0
000164114 0247_ $$2doi$$a10.3233/JAD-215416
000164114 0247_ $$2pmid$$apmid:35275535
000164114 0247_ $$2ISSN$$a1387-2877
000164114 0247_ $$2ISSN$$a1875-8908
000164114 0247_ $$2altmetric$$aaltmetric:124920905
000164114 037__ $$aDZNE-2022-00777
000164114 041__ $$aEnglish
000164114 082__ $$a610
000164114 1001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b0$$eFirst author
000164114 245__ $$aRelevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease.
000164114 260__ $$aAmsterdam$$bIOS Press$$c2022
000164114 3367_ $$2DRIVER$$aarticle
000164114 3367_ $$2DataCite$$aOutput Types/Journal article
000164114 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1710928856_2066
000164114 3367_ $$2BibTeX$$aARTICLE
000164114 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000164114 3367_ $$00$$2EndNote$$aJournal Article
000164114 520__ $$aIt is unclear whether subjective cognitive decline (SCD) is a relevant clinical marker of incipient Alzheimer's disease (AD) and future cognitive deterioration in individuals with a family history of AD (FHAD).To investigate the association of SCD with cross-sectional cerebrospinal fluid (CSF) AD biomarker levels and cognitive decline in cognitively normal older adults with or without a first-degree FHAD.We analyzed data from cognitively normal individuals with first-degree FHAD (n = 82 'AD relatives'; mean age: 65.7 years (SD = 4.47); 59% female) and a similar group of n = 236 healthy controls without FHAD from the DELCODE study. We measured SCD with an in-depth structured interview from which we derived a SCD score, capturing features proposed to increase likelihood of underlying AD ('SCD-plus score'). We tested whether higher SCD-plus scores were associated with more pathological CSF AD biomarker levels and cognitive decline over time and whether this association varied by group.AD relatives showed higher SCD-plus scores than healthy controls and more cognitive decline over time. Higher SCD-plus scores also related stronger to cognitive change and abnormal CSF AD biomarker levels in the AD relatives as compared to the healthy controls group.Quantification of specific SCD features can provide further information on the likelihood of early AD pathology and cognitive decline among AD relatives. FHAD and SCD appear as synergistically acting enrichment strategies in AD research, the first one as a permanent indicator of genetic risk, the latter one as a correlate of disease progression.
000164114 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000164114 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000164114 650_7 $$2Other$$aAlzheimer’s disease
000164114 650_7 $$2Other$$acerebrospinal fluid
000164114 650_7 $$2Other$$afamily history
000164114 650_7 $$2Other$$asubjective cognitive decline
000164114 650_2 $$2MeSH$$aAged
000164114 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000164114 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000164114 650_2 $$2MeSH$$aCognitive Dysfunction: psychology
000164114 650_2 $$2MeSH$$aCross-Sectional Studies
000164114 650_2 $$2MeSH$$aFemale
000164114 650_2 $$2MeSH$$aHumans
000164114 650_2 $$2MeSH$$aMale
000164114 650_2 $$2MeSH$$aNeuropsychological Tests
000164114 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000164114 7001_ $$0P:(DE-2719)2812139$$aKleineidam, Luca$$b1
000164114 7001_ $$0P:(DE-2719)9002221$$aWeyrauch, Anne Sophie$$b2$$udzne
000164114 7001_ $$0P:(DE-2719)2812114$$aBarkhoff, Miriam$$b3
000164114 7001_ $$0P:(DE-2719)2810395$$aRöske, Sandra$$b4
000164114 7001_ $$0P:(DE-2719)2811024$$aPeters, Oliver$$b5
000164114 7001_ $$0P:(DE-2719)9000703$$aPreis, Lukas$$b6
000164114 7001_ $$0P:(DE-2719)9001704$$aGref, Daria$$b7
000164114 7001_ $$0P:(DE-2719)2812446$$aSpruth, Eike Jakob$$b8
000164114 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b9
000164114 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b10
000164114 7001_ $$0P:(DE-2719)2811326$$aFließbach, Klaus$$b11
000164114 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b12
000164114 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b13
000164114 7001_ $$0P:(DE-2719)9000444$$aBartels, Claudia$$b14
000164114 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b15
000164114 7001_ $$0P:(DE-HGF)0$$aMaier, Franziska$$b16
000164114 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b17
000164114 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline$$b18
000164114 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b19
000164114 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b20
000164114 7001_ $$0P:(DE-HGF)0$$aJanowitz, Daniel$$b21
000164114 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b22
000164114 7001_ $$0P:(DE-2719)9001808$$aRauchmann, Boris Stephan$$b23
000164114 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b24
000164114 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b25
000164114 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b26
000164114 7001_ $$0P:(DE-2719)9001516$$aMunk, Matthias H$$b27
000164114 7001_ $$0P:(DE-2719)2812341$$aRoy, Nina$$b28
000164114 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b29
000164114 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b30
000164114 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T$$b31
000164114 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b32
000164114 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b33$$eLast author
000164114 7001_ $$agroup, DELCODE study$$b34$$eCollaboration Author
000164114 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-215416$$gVol. 87, no. 2, p. 545 - 555$$n2$$p545 - 555$$tJournal of Alzheimer's disease$$v87$$x1387-2877$$y2022
000164114 8564_ $$uhttps://pub.dzne.de/record/164114/files/DZNE-2022-00777_Restricted.pdf
000164114 8564_ $$uhttps://pub.dzne.de/record/164114/files/DZNE-2022-00777_Restricted.pdf?subformat=pdfa$$xpdfa
000164114 909CO $$ooai:pub.dzne.de:164114$$pVDB
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810544$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812139$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9002221$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812114$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810395$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811024$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000164114 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000703$$aExternal Institute$$b6$$kExtern
000164114 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001704$$aExternal Institute$$b7$$kExtern
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812446$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811720$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b9$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811326$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811317$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b13$$kDZNE
000164114 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9000444$$aExternal Institute$$b14$$kExtern
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000032$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000005$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b17$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000443$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b18$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811614$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b19$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811351$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b20$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812234$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b22$$kDZNE
000164114 9101_ $$0I:(DE-HGF)0$$6P:(DE-2719)9001808$$aExternal Institute$$b23$$kExtern
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810394$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b24$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b25$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000055$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b26$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9001516$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b27$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812341$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b28$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811324$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b29$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812825$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b30$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000008$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b31$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810593$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b32$$kDZNE
000164114 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000057$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b33$$kDZNE
000164114 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000164114 9141_ $$y2022
000164114 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-04
000164114 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-04
000164114 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-04
000164114 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ ALZHEIMERS DIS : 2021$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-18
000164114 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-18
000164114 9201_ $$0I:(DE-2719)1011201$$kAG Wagner$$lNeuropsychology$$x0
000164114 9201_ $$0I:(DE-2719)1011101$$kPatient Studies Bonn$$lPatient Studies Bonn$$x1
000164114 9201_ $$0I:(DE-2719)1811005$$kAG Endres$$lInterdisciplinary Dementia Research$$x2
000164114 9201_ $$0I:(DE-2719)5000007$$kAG Priller$$lTranslational Neuropsychiatry$$x3
000164114 9201_ $$0I:(DE-2719)1011305$$kAG Schneider$$lTranslational Dementia Research (Bonn)$$x4
000164114 9201_ $$0I:(DE-2719)1410006$$kAG Wiltfang$$lMolecular biomarkers for predictive diagnostics of neurodegenerative diseases$$x5
000164114 9201_ $$0I:(DE-2719)1340013$$kKAP$$lCooperation Unit for Applied Prevention Research (KAP)$$x6
000164114 9201_ $$0I:(DE-2719)5000006$$kAG Düzel$$lClinical Neurophysiology and Memory$$x7
000164114 9201_ $$0I:(DE-2719)5000022$$kAG Dichgans$$lVascular Cognitive Impairment & Post-Stroke Dementia$$x8
000164114 9201_ $$0I:(DE-2719)1510100$$kAG Teipel$$lClinical Dementia Research (Rostock /Greifswald)$$x9
000164114 9201_ $$0I:(DE-2719)1240005$$kCore ICRU$$lCore ICRU$$x10
000164114 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x11
000164114 9201_ $$0I:(DE-2719)1011401$$kClinical Research Platform (CRP)$$lClinical Research Platform (CRP)$$x12
000164114 9201_ $$0I:(DE-2719)1011001$$kAG Klockgether$$lPatient Studies$$x13
000164114 9201_ $$0I:(DE-2719)1011301$$kBiomarker$$lInterventional Trials and Biomarkers in Neurodegenerative Diseases$$x14
000164114 9201_ $$0I:(DE-2719)5000034$$kDelcode$$lDelcode$$x15
000164114 980__ $$ajournal
000164114 980__ $$aVDB
000164114 980__ $$aI:(DE-2719)1011201
000164114 980__ $$aI:(DE-2719)1011101
000164114 980__ $$aI:(DE-2719)1811005
000164114 980__ $$aI:(DE-2719)5000007
000164114 980__ $$aI:(DE-2719)1011305
000164114 980__ $$aI:(DE-2719)1410006
000164114 980__ $$aI:(DE-2719)1340013
000164114 980__ $$aI:(DE-2719)5000006
000164114 980__ $$aI:(DE-2719)5000022
000164114 980__ $$aI:(DE-2719)1510100
000164114 980__ $$aI:(DE-2719)1240005
000164114 980__ $$aI:(DE-2719)1210000
000164114 980__ $$aI:(DE-2719)1011401
000164114 980__ $$aI:(DE-2719)1011001
000164114 980__ $$aI:(DE-2719)1011301
000164114 980__ $$aI:(DE-2719)5000034
000164114 980__ $$aUNRESTRICTED