TY  - JOUR
AU  - Wolfsgruber, Steffen
AU  - Kleineidam, Luca
AU  - Weyrauch, Anne Sophie
AU  - Barkhoff, Miriam
AU  - Röske, Sandra
AU  - Peters, Oliver
AU  - Preis, Lukas
AU  - Gref, Daria
AU  - Spruth, Eike Jakob
AU  - Altenstein, Slawek
AU  - Priller, Josef
AU  - Fließbach, Klaus
AU  - Schneider, Anja
AU  - Wiltfang, Jens
AU  - Bartels, Claudia
AU  - Jessen, Frank
AU  - Maier, Franziska
AU  - Düzel, Emrah
AU  - Metzger, Coraline
AU  - Glanz, Wenzel
AU  - Bürger, Katharina
AU  - Janowitz, Daniel
AU  - Perneczky, Robert
AU  - Rauchmann, Boris Stephan
AU  - Kilimann, Ingo
AU  - Teipel, Stefan
AU  - Laske, Christoph
AU  - Munk, Matthias H
AU  - Roy, Nina
AU  - Spottke, Annika
AU  - Ramirez, Alfredo
AU  - Heneka, Michael T
AU  - Brosseron, Frederic
AU  - Wagner, Michael
TI  - Relevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease.
JO  - Journal of Alzheimer's disease
VL  - 87
IS  - 2
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2022-00777
SP  - 545 - 555
PY  - 2022
AB  - It is unclear whether subjective cognitive decline (SCD) is a relevant clinical marker of incipient Alzheimer's disease (AD) and future cognitive deterioration in individuals with a family history of AD (FHAD).To investigate the association of SCD with cross-sectional cerebrospinal fluid (CSF) AD biomarker levels and cognitive decline in cognitively normal older adults with or without a first-degree FHAD.We analyzed data from cognitively normal individuals with first-degree FHAD (n = 82 'AD relatives'; mean age: 65.7 years (SD = 4.47); 59
KW  - Aged
KW  - Alzheimer Disease: pathology
KW  - Biomarkers: cerebrospinal fluid
KW  - Cognitive Dysfunction: psychology
KW  - Cross-Sectional Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Neuropsychological Tests
KW  - Alzheimer’s disease (Other)
KW  - cerebrospinal fluid (Other)
KW  - family history (Other)
KW  - subjective cognitive decline (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35275535
DO  - DOI:10.3233/JAD-215416
UR  - https://pub.dzne.de/record/164114
ER  -