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@ARTICLE{Wolfsgruber:164114,
      author       = {Wolfsgruber, Steffen and Kleineidam, Luca and Weyrauch,
                      Anne Sophie and Barkhoff, Miriam and Röske, Sandra and
                      Peters, Oliver and Preis, Lukas and Gref, Daria and Spruth,
                      Eike Jakob and Altenstein, Slawek and Priller, Josef and
                      Fließbach, Klaus and Schneider, Anja and Wiltfang, Jens and
                      Bartels, Claudia and Jessen, Frank and Maier, Franziska and
                      Düzel, Emrah and Metzger, Coraline and Glanz, Wenzel and
                      Bürger, Katharina and Janowitz, Daniel and Perneczky,
                      Robert and Rauchmann, Boris Stephan and Kilimann, Ingo and
                      Teipel, Stefan and Laske, Christoph and Munk, Matthias H and
                      Roy, Nina and Spottke, Annika and Ramirez, Alfredo and
                      Heneka, Michael T and Brosseron, Frederic and Wagner,
                      Michael},
      collaboration = {group, DELCODE study},
      title        = {{R}elevance of {S}ubjective {C}ognitive {D}ecline in
                      {O}lder {A}dults with a {F}irst-{D}egree {F}amily {H}istory
                      of {A}lzheimer's {D}isease.},
      journal      = {Journal of Alzheimer's disease},
      volume       = {87},
      number       = {2},
      issn         = {1387-2877},
      address      = {Amsterdam},
      publisher    = {IOS Press},
      reportid     = {DZNE-2022-00777},
      pages        = {545 - 555},
      year         = {2022},
      abstract     = {It is unclear whether subjective cognitive decline (SCD) is
                      a relevant clinical marker of incipient Alzheimer's disease
                      (AD) and future cognitive deterioration in individuals with
                      a family history of AD (FHAD).To investigate the association
                      of SCD with cross-sectional cerebrospinal fluid (CSF) AD
                      biomarker levels and cognitive decline in cognitively normal
                      older adults with or without a first-degree FHAD.We analyzed
                      data from cognitively normal individuals with first-degree
                      FHAD (n = 82 'AD relatives'; mean age: 65.7 years (SD =
                      4.47); $59\%$ female) and a similar group of n = 236 healthy
                      controls without FHAD from the DELCODE study. We measured
                      SCD with an in-depth structured interview from which we
                      derived a SCD score, capturing features proposed to increase
                      likelihood of underlying AD ('SCD-plus score'). We tested
                      whether higher SCD-plus scores were associated with more
                      pathological CSF AD biomarker levels and cognitive decline
                      over time and whether this association varied by group.AD
                      relatives showed higher SCD-plus scores than healthy
                      controls and more cognitive decline over time. Higher
                      SCD-plus scores also related stronger to cognitive change
                      and abnormal CSF AD biomarker levels in the AD relatives as
                      compared to the healthy controls group.Quantification of
                      specific SCD features can provide further information on the
                      likelihood of early AD pathology and cognitive decline among
                      AD relatives. FHAD and SCD appear as synergistically acting
                      enrichment strategies in AD research, the first one as a
                      permanent indicator of genetic risk, the latter one as a
                      correlate of disease progression.},
      keywords     = {Aged / Alzheimer Disease: pathology / Biomarkers:
                      cerebrospinal fluid / Cognitive Dysfunction: psychology /
                      Cross-Sectional Studies / Female / Humans / Male /
                      Neuropsychological Tests / Alzheimer’s disease (Other) /
                      cerebrospinal fluid (Other) / family history (Other) /
                      subjective cognitive decline (Other)},
      cin          = {AG Wagner / Patient Studies Bonn / AG Endres / AG Priller /
                      AG Schneider / AG Wiltfang / KAP / AG Düzel / AG Dichgans /
                      AG Teipel / Core ICRU / AG Gasser / Clinical Research
                      Platform (CRP) / AG Klockgether / Biomarker / Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)1011201 / I:(DE-2719)1011101 /
                      I:(DE-2719)1811005 / I:(DE-2719)5000007 / I:(DE-2719)1011305
                      / I:(DE-2719)1410006 / I:(DE-2719)1340013 /
                      I:(DE-2719)5000006 / I:(DE-2719)5000022 / I:(DE-2719)1510100
                      / I:(DE-2719)1240005 / I:(DE-2719)1210000 /
                      I:(DE-2719)1011401 / I:(DE-2719)1011001 / I:(DE-2719)1011301
                      / I:(DE-2719)5000034},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35275535},
      doi          = {10.3233/JAD-215416},
      url          = {https://pub.dzne.de/record/164114},
}