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000164142 0247_ $$2doi$$a10.1002/alz.12485
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000164142 037__ $$aDZNE-2022-00798
000164142 041__ $$aEnglish
000164142 082__ $$a610
000164142 1001_ $$aBenussi, Alberto$$b0
000164142 245__ $$aConceptual framework for the definition of preclinical and prodromal frontotemporal dementia.
000164142 260__ $$aHoboken, NJ$$bWiley$$c2022
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000164142 520__ $$aThe presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.
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000164142 650_7 $$2Other$$adefinition
000164142 650_7 $$2Other$$afrontotemporal dementia
000164142 650_7 $$2Other$$afrontotemporal lobar degeneration
000164142 650_7 $$2Other$$amild cognitive and/or behavioral and/or motor impairment
000164142 650_7 $$2Other$$amild cognitive impairment
000164142 650_7 $$2Other$$apreclinical
000164142 650_7 $$2Other$$apresymptomatic
000164142 650_7 $$2Other$$aprodromal
000164142 650_2 $$2MeSH$$aFrontotemporal Dementia: diagnosis
000164142 650_2 $$2MeSH$$aFrontotemporal Dementia: genetics
000164142 650_2 $$2MeSH$$aHumans
000164142 650_2 $$2MeSH$$aProdromal Symptoms
000164142 7001_ $$aAlberici, Antonella$$b1
000164142 7001_ $$aSamra, Kiran$$b2
000164142 7001_ $$aRussell, Lucy L$$b3
000164142 7001_ $$aGreaves, Caroline V$$b4
000164142 7001_ $$aBocchetta, Martina$$b5
000164142 7001_ $$aDucharme, Simon$$b6
000164142 7001_ $$aFinger, Elizabeth$$b7
000164142 7001_ $$aFumagalli, Giorgio$$b8
000164142 7001_ $$aGalimberti, Daniela$$b9
000164142 7001_ $$aJiskoot, Lize C$$b10
000164142 7001_ $$aLe Ber, Isabelle$$b11
000164142 7001_ $$aMasellis, Mario$$b12
000164142 7001_ $$aNacmias, Benedetta$$b13
000164142 7001_ $$aRowe, James B$$b14
000164142 7001_ $$aSanchez-Valle, Raquel$$b15
000164142 7001_ $$aSeelaar, Harro$$b16
000164142 7001_ $$0P:(DE-2719)2811275$$aSynofzik, Matthis$$b17$$udzne
000164142 7001_ $$aConsortium, GENFI$$b18$$eCollaboration Author
000164142 7001_ $$aRohrer, Jonathan D$$b19
000164142 7001_ $$aBorroni, Barbara$$b20
000164142 7001_ $$aAfonso, Sónia$$b21
000164142 7001_ $$aAlmeida, Maria Rosario$$b22
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