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@ARTICLE{Benussi:164142,
author = {Benussi, Alberto and Alberici, Antonella and Samra, Kiran
and Russell, Lucy L and Greaves, Caroline V and Bocchetta,
Martina and Ducharme, Simon and Finger, Elizabeth and
Fumagalli, Giorgio and Galimberti, Daniela and Jiskoot, Lize
C and Le Ber, Isabelle and Masellis, Mario and Nacmias,
Benedetta and Rowe, James B and Sanchez-Valle, Raquel and
Seelaar, Harro and Synofzik, Matthis and Rohrer, Jonathan D
and Borroni, Barbara and Afonso, Sónia and Almeida, Maria
Rosario and Anderl-Straub, Sarah and Andersson, Christin and
Antonell, Anna and Archetti, Silvana and Arighi, Andrea and
Balasa, Mircea and Barandiaran, Myriam and Bargalló, Nuria
and Bartha, Robart and Bender, Benjamin and Bertoux, Maxime
and Bertrand, Anne and Bessi, Valentina and Black, Sandra
and Borrego-Ecija, Sergi and Bouzigues, Arabella and Bras,
Jose and Brice, Alexis and Bruffaerts, Rose and Butler,
Chris R and Camuzat, Agnès and Cañada, Marta and Cantoni,
Valentina and Caroppo, Paola and Cash, David and
Castelo-Branco, Miguel and Colliot, Olivier and Convery,
Rhian and Cope, Thomas and Danek, Adrian and de Mendonça,
Alexandre and Deramecourt, Vincent and Di Fede, Giuseppe and
Díez, Alina and Duro, Diana and Fenoglio, Chiara and
Ferrari, Camilla and Ferreira, Catarina B and Fox, Nick and
Freedman, Morris and Funkiewiez, Aurélie and Gabilondo,
Alazne and Gauthier, Serge and Gazzina, Stefano and Gerhard,
Alexander and Giaccone, Giorgio and Gorostidi, Ana and
Graff, Caroline and Guerreiro, Rita and Heller, Carolin and
Hoegen, Tobias and Indakoetxea, Begoña and Jelic, Vesna and
Karnath, Hans Otto and Keren, Ron and Kuchcinski, Gregory
and Laforce, Robert and Waldo, Maria Landqvist and
Langheinrich, Tobias and Lebouvier, Thibaud and Leitão,
Maria João and Levin, Johannes and Lladó, Albert and
Lombardi, Gemma and Lombardi, Jolina and Loosli, Sandra and
Maruta, Carolina and Mead, Simon and Meeter, Lieke and
Miltenberger, Gabriel and van Minkelen, Rick and Mitchell,
Sara and Moore, Katrina and Moreno, Fermin and Nelson,
Annabel and Nicholas, Jennifer and Öijerstedt, Linn and
Olives, Jaume and Otto, Markus and Ourselin, Sebastien and
Panman, Jessica and Papma, Janne M and Pasquier, Florence
and Pijnenburg, Yolande and Polito, Cristina and Premi,
Enrico and Prioni, Sara and Prix, Catharina and Rademakers,
Rosa and Redaelli, Veronica and Rinaldi, Daisy and Rittman,
Tim and Rogaeva, Ekaterina and Rollin, Adeline and
Rosa-Neto, Pedro and Rossi, Giacomina and Rossor, Martin and
Santana, Isabel and Santiago, Beatriz and Saracino, Dario
and Sayah, Sabrina and Scarpini, Elio and Schönecker, Sonja
and Schroeter, Matthias and Shafei, Rachelle and Shoesmith,
Christen and Sorbi, Sandro and Swift, Imogen and
Tábuas-Pereira, Miguel and Pijnenburg, Yolande and
Tagliavini, Fabrizio and Tainta, Mikel and Taipa, Ricardo
and Tang-Wai, David and Tartaglia, Carmela and Thomas, David
L and Thompson, Paul and Thonberg, Hakan and Timberlake,
Carolyn and Tiraboschi, Pietro and Todd, Emily and Van
Damme, Philip and Vandenberghe, Rik and Vandenbulcke,
Mathieu and van Swieten, John C and Veldsman, Michele and
Verdelho, Ana and Villanua, Jorge and Warren, Jason and
Wilke, Carlo and Woollacott, Ione and Wlasich, Elisabeth and
Zetterberg, Henrik and Zulaica, Miren},
collaboration = {Consortium, GENFI},
title = {{C}onceptual framework for the definition of preclinical
and prodromal frontotemporal dementia.},
journal = {Alzheimer's and dementia},
volume = {18},
number = {7},
issn = {1552-5260},
address = {Hoboken, NJ},
publisher = {Wiley},
reportid = {DZNE-2022-00798},
pages = {1408-1423},
year = {2022},
note = {(CC BY 4.0)},
abstract = {The presymptomatic stages of frontotemporal dementia (FTD)
are still poorly defined and encompass a long accrual of
progressive biological (preclinical) and then clinical
(prodromal) changes, antedating the onset of dementia. The
heterogeneity of clinical presentations and the different
neuropathological phenotypes have prevented a prior clear
description of either preclinical or prodromal FTD. Recent
advances in therapeutic approaches, at least in monogenic
disease, demand a proper definition of these predementia
stages. It has become clear that a consensus lexicon is
needed to comprehensively describe the stages that
anticipate dementia. The goal of the present work is to
review existing literature on the preclinical and prodromal
phases of FTD, providing recommendations to address the
unmet questions, therefore laying out a strategy for
operationalizing and better characterizing these
presymptomatic disease stages.},
keywords = {Frontotemporal Dementia: diagnosis / Frontotemporal
Dementia: genetics / Humans / Prodromal Symptoms /
definition (Other) / frontotemporal dementia (Other) /
frontotemporal lobar degeneration (Other) / mild cognitive
and/or behavioral and/or motor impairment (Other) / mild
cognitive impairment (Other) / preclinical (Other) /
presymptomatic (Other) / prodromal (Other)},
cin = {AG Gasser 1},
ddc = {610},
cid = {I:(DE-2719)1210000},
pnm = {353 - Clinical and Health Care Research (POF4-353)},
pid = {G:(DE-HGF)POF4-353},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:34874596},
doi = {10.1002/alz.12485},
url = {https://pub.dzne.de/record/164142},
}
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