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000164153 0247_ $$2doi$$a10.1016/j.pbiomolbio.2021.06.003
000164153 0247_ $$2pmid$$apmid:34129872
000164153 0247_ $$2ISSN$$a0079-6107
000164153 0247_ $$2ISSN$$a1873-1732
000164153 037__ $$aDZNE-2022-00809
000164153 041__ $$aEnglish
000164153 082__ $$a570
000164153 1001_ $$aDiFrancesco, Mattia L$$b0
000164153 245__ $$aThe funny current in genetically modified mice.
000164153 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2021
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000164153 520__ $$aSince its first description in 1979, the hyperpolarization-activated funny current (If) has been the object of intensive research aimed at understanding its role in cardiac pacemaker activity and its modulation by the sympathetic and parasympathetic branches of the autonomic nervous system. If was described in isolated tissue strips of the rabbit sinoatrial node using the double-electrode voltage-clamp technique. Since then, the rabbit has been the principal animal model for studying pacemaker activity and If for more than 20 years. In 2001, the first study describing the electrophysiological properties of mouse sinoatrial pacemaker myocytes and those of If was published. It was soon followed by the description of murine myocytes of the atrioventricular node and the Purkinje fibres. The sinoatrial node of genetically modified mice has become a very popular model for studying the mechanisms of cardiac pacemaker activity. This field of research benefits from the impressive advancement of in-vivo exploration techniques of physiological parameters, imaging, genetics, and large-scale genomic approaches. The present review discusses the influence of mouse genetic on the most recent knowledge of the funny current's role in the physiology and pathophysiology of cardiac pacemaker activity. Genetically modified mice have provided important insights into the role of If in determining intrinsic automaticity in vivo and in myocytes of the conduction system. In addition, gene targeting of f-(HCN) channel isoforms have contributed to elucidating the current's role in the regulation of heart rate by the parasympathetic nervous system. This review is dedicated to Dario DiFrancesco on his retirement.
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000164153 650_7 $$2Other$$aCardiac pacemaker activity
000164153 650_7 $$2Other$$aConduction system
000164153 650_7 $$2Other$$aFunny current
000164153 650_7 $$2Other$$aGenetically modified mice
000164153 650_7 $$2Other$$aRhythmogenesis
000164153 650_7 $$2Other$$aSinoatrial node
000164153 650_7 $$2NLM Chemicals$$aHyperpolarization-Activated Cyclic Nucleotide-Gated Channels
000164153 650_2 $$2MeSH$$aAnimals
000164153 650_2 $$2MeSH$$aElectrophysiological Phenomena
000164153 650_2 $$2MeSH$$aHeart Rate
000164153 650_2 $$2MeSH$$aHyperpolarization-Activated Cyclic Nucleotide-Gated Channels
000164153 650_2 $$2MeSH$$aMice
000164153 650_2 $$2MeSH$$aPatch-Clamp Techniques
000164153 650_2 $$2MeSH$$aRabbits
000164153 650_2 $$2MeSH$$aSinoatrial Node
000164153 7001_ $$aMesirca, Pietro$$b1
000164153 7001_ $$aBidaud, Isabelle$$b2
000164153 7001_ $$0P:(DE-2719)2810976$$aIsbrandt, Dirk$$b3$$udzne
000164153 7001_ $$aMangoni, Matteo E$$b4
000164153 773__ $$0PERI:(DE-600)1498578-0$$a10.1016/j.pbiomolbio.2021.06.003$$gVol. 166, p. 39 - 50$$p39 - 50$$tProgress in biophysics & molecular biology$$v166$$x0079-6107$$y2021
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