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@ARTICLE{DiFrancesco:164153,
      author       = {DiFrancesco, Mattia L and Mesirca, Pietro and Bidaud,
                      Isabelle and Isbrandt, Dirk and Mangoni, Matteo E},
      title        = {{T}he funny current in genetically modified mice.},
      journal      = {Progress in biophysics $\&$ molecular biology},
      volume       = {166},
      issn         = {0079-6107},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2022-00809},
      pages        = {39 - 50},
      year         = {2021},
      abstract     = {Since its first description in 1979, the
                      hyperpolarization-activated funny current (If) has been the
                      object of intensive research aimed at understanding its role
                      in cardiac pacemaker activity and its modulation by the
                      sympathetic and parasympathetic branches of the autonomic
                      nervous system. If was described in isolated tissue strips
                      of the rabbit sinoatrial node using the double-electrode
                      voltage-clamp technique. Since then, the rabbit has been the
                      principal animal model for studying pacemaker activity and
                      If for more than 20 years. In 2001, the first study
                      describing the electrophysiological properties of mouse
                      sinoatrial pacemaker myocytes and those of If was published.
                      It was soon followed by the description of murine myocytes
                      of the atrioventricular node and the Purkinje fibres. The
                      sinoatrial node of genetically modified mice has become a
                      very popular model for studying the mechanisms of cardiac
                      pacemaker activity. This field of research benefits from the
                      impressive advancement of in-vivo exploration techniques of
                      physiological parameters, imaging, genetics, and large-scale
                      genomic approaches. The present review discusses the
                      influence of mouse genetic on the most recent knowledge of
                      the funny current's role in the physiology and
                      pathophysiology of cardiac pacemaker activity. Genetically
                      modified mice have provided important insights into the role
                      of If in determining intrinsic automaticity in vivo and in
                      myocytes of the conduction system. In addition, gene
                      targeting of f-(HCN) channel isoforms have contributed to
                      elucidating the current's role in the regulation of heart
                      rate by the parasympathetic nervous system. This review is
                      dedicated to Dario DiFrancesco on his retirement.},
      subtyp        = {Review Article},
      keywords     = {Animals / Electrophysiological Phenomena / Heart Rate /
                      Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
                      / Mice / Patch-Clamp Techniques / Rabbits / Sinoatrial Node
                      / Cardiac pacemaker activity (Other) / Conduction system
                      (Other) / Funny current (Other) / Genetically modified mice
                      (Other) / Rhythmogenesis (Other) / Sinoatrial node (Other) /
                      Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
                      (NLM Chemicals)},
      cin          = {AG Isbrandt},
      ddc          = {570},
      cid          = {I:(DE-2719)1011003},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34129872},
      doi          = {10.1016/j.pbiomolbio.2021.06.003},
      url          = {https://pub.dzne.de/record/164153},
}