%0 Journal Article
%A Vockert, Niklas
%A Perosa, Valentina
%A Ziegler, Gabriel
%A Schreiber, Frank
%A Priester, Anastasia
%A Spallazzi, Marco
%A Garcia-Garcia, Berta
%A Aruci, Merita
%A Mattern, Hendrik
%A Haghikia, Aiden
%A Düzel, Emrah
%A Schreiber, Stefanie
%A Maaß, Anne
%T Hippocampal vascularization patterns exert local and distant effects on brain structure but not vascular pathology in old age.
%J Brain communications
%V 3
%N 3
%@ 2632-1297
%C [Großbritannien]
%I Guarantors of Brain
%M DZNE-2022-00823
%P fcab127
%D 2021
%X The hippocampus within the medial temporal lobe is highly vulnerable to age-related pathology such as vascular disease. We examined hippocampal vascularization patterns by harnessing the ultra-high resolution of 7 Tesla magnetic resonance angiography. Dual-supply hemispheres with a contribution of the anterior choroidal artery to hippocampal blood supply were distinguished from single-supply ones with a sole dependence on the posterior cerebral artery. A recent study indicated that a dual vascular supply is related to preserved cognition and structural hippocampal integrity in old age and vascular disease. Here, we examined the regional specificity of these structural benefits at the level of medial temporal lobe sub-regions and hemispheres. In a cross-sectional study with an older cohort of 17 patients with cerebral small vessel disease (70.7 ± 9.0 years, 35.5
%K brain structure (Other)
%K cerebral small vessel disease (Other)
%K resilience (Other)
%K resistance (Other)
%K vascularization (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:34222874
%2 pmc:PMC8249103
%R 10.1093/braincomms/fcab127
%U https://pub.dzne.de/record/164167