TY  - JOUR
AU  - Vockert, Niklas
AU  - Perosa, Valentina
AU  - Ziegler, Gabriel
AU  - Schreiber, Frank
AU  - Priester, Anastasia
AU  - Spallazzi, Marco
AU  - Garcia-Garcia, Berta
AU  - Aruci, Merita
AU  - Mattern, Hendrik
AU  - Haghikia, Aiden
AU  - Düzel, Emrah
AU  - Schreiber, Stefanie
AU  - Maaß, Anne
TI  - Hippocampal vascularization patterns exert local and distant effects on brain structure but not vascular pathology in old age.
JO  - Brain communications
VL  - 3
IS  - 3
SN  - 2632-1297
CY  - [Großbritannien]
PB  - Guarantors of Brain
M1  - DZNE-2022-00823
SP  - fcab127
PY  - 2021
AB  - The hippocampus within the medial temporal lobe is highly vulnerable to age-related pathology such as vascular disease. We examined hippocampal vascularization patterns by harnessing the ultra-high resolution of 7 Tesla magnetic resonance angiography. Dual-supply hemispheres with a contribution of the anterior choroidal artery to hippocampal blood supply were distinguished from single-supply ones with a sole dependence on the posterior cerebral artery. A recent study indicated that a dual vascular supply is related to preserved cognition and structural hippocampal integrity in old age and vascular disease. Here, we examined the regional specificity of these structural benefits at the level of medial temporal lobe sub-regions and hemispheres. In a cross-sectional study with an older cohort of 17 patients with cerebral small vessel disease (70.7 ± 9.0 years, 35.5
KW  - brain structure (Other)
KW  - cerebral small vessel disease (Other)
KW  - resilience (Other)
KW  - resistance (Other)
KW  - vascularization (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:34222874
C2  - pmc:PMC8249103
DO  - DOI:10.1093/braincomms/fcab127
UR  - https://pub.dzne.de/record/164167
ER  -