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@ARTICLE{Vockert:164167,
      author       = {Vockert, Niklas and Perosa, Valentina and Ziegler, Gabriel
                      and Schreiber, Frank and Priester, Anastasia and Spallazzi,
                      Marco and Garcia-Garcia, Berta and Aruci, Merita and
                      Mattern, Hendrik and Haghikia, Aiden and Düzel, Emrah and
                      Schreiber, Stefanie and Maaß, Anne},
      title        = {{H}ippocampal vascularization patterns exert local and
                      distant effects on brain structure but not vascular
                      pathology in old age.},
      journal      = {Brain communications},
      volume       = {3},
      number       = {3},
      issn         = {2632-1297},
      address      = {[Großbritannien]},
      publisher    = {Guarantors of Brain},
      reportid     = {DZNE-2022-00823},
      pages        = {fcab127},
      year         = {2021},
      abstract     = {The hippocampus within the medial temporal lobe is highly
                      vulnerable to age-related pathology such as vascular
                      disease. We examined hippocampal vascularization patterns by
                      harnessing the ultra-high resolution of 7 Tesla magnetic
                      resonance angiography. Dual-supply hemispheres with a
                      contribution of the anterior choroidal artery to hippocampal
                      blood supply were distinguished from single-supply ones with
                      a sole dependence on the posterior cerebral artery. A recent
                      study indicated that a dual vascular supply is related to
                      preserved cognition and structural hippocampal integrity in
                      old age and vascular disease. Here, we examined the regional
                      specificity of these structural benefits at the level of
                      medial temporal lobe sub-regions and hemispheres. In a
                      cross-sectional study with an older cohort of 17 patients
                      with cerebral small vessel disease (70.7 ± 9.0 years,
                      $35.5\%$ female) and 27 controls (71.1 ± 8.2 years,
                      $44.4\%$ female), we demonstrate that differences in grey
                      matter volumes related to the hippocampal vascularization
                      pattern were specifically observed in the anterior
                      hippocampus and entorhinal cortex. These regions were
                      especially bigger in dual-supply hemispheres, but also
                      seemed to benefit from a contralateral dual supply. We
                      further show that total grey matter volumes were greater in
                      people with at least one dual-supply hemisphere, indicating
                      that the hippocampal vascularization pattern has more
                      far-reaching structural implications beyond the medial
                      temporal lobe. A mediation analysis identified total grey
                      matter as a mediator of differences in global cognition.
                      However, our analyses on multiple neuroimaging markers for
                      cerebral small vessel disease did not reveal any evidence
                      that an augmented hippocampal vascularization conveys
                      resistance nor resilience against vascular pathology. We
                      propose that an augmented hippocampal vascularization might
                      contribute to maintaining structural integrity in the brain
                      and preserving cognition despite age-related degeneration.
                      As such, the binary hippocampal vascularization pattern
                      could have major implications for brain structure and
                      function in ageing and dementia independent of vascular
                      pathology, while presenting a simple framework with
                      potential applicability to the clinical setting.},
      keywords     = {brain structure (Other) / cerebral small vessel disease
                      (Other) / resilience (Other) / resistance (Other) /
                      vascularization (Other)},
      cin          = {AG Maaß / AG Düzel / U Clinical Researchers - Magdeburg /
                      AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)1311001 / I:(DE-2719)5000006 /
                      I:(DE-2719)7000000 / I:(DE-2719)1310010},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:34222874},
      pmc          = {pmc:PMC8249103},
      doi          = {10.1093/braincomms/fcab127},
      url          = {https://pub.dzne.de/record/164167},
}