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000164199 037__ $$aDZNE-2022-00855
000164199 041__ $$aEnglish
000164199 082__ $$a570
000164199 1001_ $$aGrabrucker, Stefanie$$b0
000164199 245__ $$aActivation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
000164199 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2021
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000164199 520__ $$aImpairments in social relationships and awareness are features observed in autism spectrum disorders (ASDs). However, the underlying mechanisms remain poorly understood. Shank2 is a high-confidence ASD candidate gene and localizes primarily to postsynaptic densities (PSDs) of excitatory synapses in the central nervous system (CNS). We show here that loss of Shank2 in mice leads to a lack of social attachment and bonding behavior towards pubs independent of hormonal, cognitive, or sensitive deficits. Shank2-/- mice display functional changes in nuclei of the social attachment circuit that were most prominent in the medial preoptic area (MPOA) of the hypothalamus. Selective enhancement of MPOA activity by DREADD technology re-established social bonding behavior in Shank2-/- mice, providing evidence that the identified circuit might be crucial for explaining how social deficits in ASD can arise.
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000164199 650_7 $$2Other$$aSHANK3
000164199 650_7 $$2Other$$aautism spectrum disorders
000164199 650_7 $$2Other$$abonding
000164199 650_7 $$2Other$$asocial behavior
000164199 650_7 $$2Other$$asynapse
000164199 650_7 $$2NLM Chemicals$$aDREADD agonist compound 21
000164199 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000164199 650_7 $$2NLM Chemicals$$aPiperazines
000164199 650_7 $$2NLM Chemicals$$aShank2 protein, mouse
000164199 650_2 $$2MeSH$$aAnimals
000164199 650_2 $$2MeSH$$aAutistic Disorder: drug therapy
000164199 650_2 $$2MeSH$$aAutistic Disorder: etiology
000164199 650_2 $$2MeSH$$aAutistic Disorder: metabolism
000164199 650_2 $$2MeSH$$aAutistic Disorder: pathology
000164199 650_2 $$2MeSH$$aDisease Models, Animal
000164199 650_2 $$2MeSH$$aFemale
000164199 650_2 $$2MeSH$$aInterpersonal Relations
000164199 650_2 $$2MeSH$$aMale
000164199 650_2 $$2MeSH$$aMaternal Behavior: drug effects
000164199 650_2 $$2MeSH$$aMice
000164199 650_2 $$2MeSH$$aMice, Inbred C57BL
000164199 650_2 $$2MeSH$$aMice, Knockout
000164199 650_2 $$2MeSH$$aNerve Tissue Proteins: physiology
000164199 650_2 $$2MeSH$$aPiperazines: pharmacology
000164199 650_2 $$2MeSH$$aPreoptic Area: drug effects
000164199 650_2 $$2MeSH$$aPreoptic Area: metabolism
000164199 650_2 $$2MeSH$$aPreoptic Area: pathology
000164199 650_2 $$2MeSH$$aSynapses
000164199 7001_ $$aPagano, Jessica$$b1
000164199 7001_ $$00000-0001-5058-6693$$aSchweizer, Johanna$$b2
000164199 7001_ $$aUrrutia-Ruiz, Carolina$$b3
000164199 7001_ $$aSchön, Michael$$b4
000164199 7001_ $$aThome, Kevin$$b5
000164199 7001_ $$aEhret, Günter$$b6
000164199 7001_ $$aGrabrucker, Andreas M$$b7
000164199 7001_ $$aZhang, Rong$$b8
000164199 7001_ $$aHengerer, Bastian$$b9
000164199 7001_ $$aBockmann, Jürgen$$b10
000164199 7001_ $$0P:(DE-2719)9000803$$aVerpelli, Chiara$$b11$$udzne
000164199 7001_ $$0P:(DE-2719)9000735$$aSala, Carlo$$b12$$udzne
000164199 7001_ $$0P:(DE-2719)2812855$$aBöckers, Tobias$$b13$$eLast author$$udzne
000164199 773__ $$0PERI:(DE-600)1467419-1$$a10.15252/embj.2019104267$$gVol. 40, no. 5$$n5$$pe104267$$tThe EMBO journal$$v40$$x0261-4189$$y2021
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