Home > Publications Database > Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism. > print

001     164199
005     20240619121039.0
024 7 _ |a 10.15252/embj.2019104267
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037 _ _ |a DZNE-2022-00855
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Grabrucker, Stefanie
|b 0
245 _ _ |a Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
260 _ _ |a Hoboken, NJ [u.a.]
|c 2021
|b Wiley
336 7 _ |a article
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520 _ _ |a Impairments in social relationships and awareness are features observed in autism spectrum disorders (ASDs). However, the underlying mechanisms remain poorly understood. Shank2 is a high-confidence ASD candidate gene and localizes primarily to postsynaptic densities (PSDs) of excitatory synapses in the central nervous system (CNS). We show here that loss of Shank2 in mice leads to a lack of social attachment and bonding behavior towards pubs independent of hormonal, cognitive, or sensitive deficits. Shank2-/- mice display functional changes in nuclei of the social attachment circuit that were most prominent in the medial preoptic area (MPOA) of the hypothalamus. Selective enhancement of MPOA activity by DREADD technology re-established social bonding behavior in Shank2-/- mice, providing evidence that the identified circuit might be crucial for explaining how social deficits in ASD can arise.
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650 _ 7 |a SHANK3
|2 Other
650 _ 7 |a autism spectrum disorders
|2 Other
650 _ 7 |a bonding
|2 Other
650 _ 7 |a social behavior
|2 Other
650 _ 7 |a synapse
|2 Other
650 _ 7 |a DREADD agonist compound 21
|2 NLM Chemicals
650 _ 7 |a Nerve Tissue Proteins
|2 NLM Chemicals
650 _ 7 |a Piperazines
|2 NLM Chemicals
650 _ 7 |a Shank2 protein, mouse
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Autistic Disorder: drug therapy
|2 MeSH
650 _ 2 |a Autistic Disorder: etiology
|2 MeSH
650 _ 2 |a Autistic Disorder: metabolism
|2 MeSH
650 _ 2 |a Autistic Disorder: pathology
|2 MeSH
650 _ 2 |a Disease Models, Animal
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Interpersonal Relations
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Maternal Behavior: drug effects
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Nerve Tissue Proteins: physiology
|2 MeSH
650 _ 2 |a Piperazines: pharmacology
|2 MeSH
650 _ 2 |a Preoptic Area: drug effects
|2 MeSH
650 _ 2 |a Preoptic Area: metabolism
|2 MeSH
650 _ 2 |a Preoptic Area: pathology
|2 MeSH
650 _ 2 |a Synapses
|2 MeSH
700 1 _ |a Pagano, Jessica
|b 1
700 1 _ |a Schweizer, Johanna
|0 0000-0001-5058-6693
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700 1 _ |a Urrutia-Ruiz, Carolina
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700 1 _ |a Schön, Michael
|b 4
700 1 _ |a Thome, Kevin
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700 1 _ |a Ehret, Günter
|b 6
700 1 _ |a Grabrucker, Andreas M
|b 7
700 1 _ |a Zhang, Rong
|b 8
700 1 _ |a Hengerer, Bastian
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700 1 _ |a Bockmann, Jürgen
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700 1 _ |a Verpelli, Chiara
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700 1 _ |a Sala, Carlo
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700 1 _ |a Böckers, Tobias
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773 _ _ |a 10.15252/embj.2019104267
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