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@ARTICLE{Schwarck:164211,
      author       = {Schwarck, Svenja and Busse, Nancy and Ziegler, Gabriel and
                      Glanz, Wenzel and Becke, Andreas and Düzel, Emrah},
      title        = {{H}eart {R}ate {V}ariability {D}uring {P}hysical {E}xercise
                      {I}s {A}ssociated {W}ith {I}mproved {C}ognitive
                      {P}erformance in {A}lzheimer's {D}ementia {P}atients—{A}
                      {L}ongitudinal {F}easibility {S}tudy},
      journal      = {Frontiers in sports and active living},
      volume       = {3},
      issn         = {2624-9367},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DZNE-2022-00867},
      pages        = {684089},
      year         = {2021},
      abstract     = {Heart rate variability (HRV) rapidly gains attention as an
                      important marker of cardiovascular autonomic modulation.
                      Moreover, there is evidence for a link between the autonomic
                      deficit measurable by reduced HRV and the hypoactivity of
                      the cholinergic system, which is prominently affected in
                      Alzheimer's disease (AD). Despite the positive influence of
                      physical exercise on cognition and its promising association
                      with HRV, previous studies did not explore the effect of
                      long-term physical exercise in older adults with AD. Taking
                      advantage of a longitudinal study we analyzed the effect of
                      a 20-week dual task training regime (3 × 15-min per week)
                      on the vagal mediated HRV index RMSSD (root mean square of
                      successive RR interval differences) during physical exercise
                      and the short-term memory performance in a AD cohort (N =
                      14). Each training contained physical exercise on a bicycle
                      ergometer while memorizing 30 successively presented
                      pictures as well as the associated post-exercise picture
                      recognition memory test. Linear-mixed modeling revealed that
                      HRV-RMSSD significantly increased over the intervention
                      time. Moreover, the reaction time in the picture recognition
                      task decreased while the accuracy remained stable.
                      Furthermore, a significantly negative relationship between
                      increased fitness measured by HRV-RMSSD and decreased
                      reaction time was observed. This feasibility study points to
                      the positive effects of a dual task regime on physical and
                      cognitive fitness in a sample with impaired cognitive
                      performance. Beyond this, the results show that the
                      responsiveness of parasympathetic system as measured with
                      HRV can be improved in patients with dementia.},
      cin          = {AG Müller / AG Düzel / KAP},
      ddc          = {796},
      cid          = {I:(DE-2719)1310003 / I:(DE-2719)5000006 /
                      I:(DE-2719)1340013},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC8319237},
      pubmed       = {pmid:34337405},
      doi          = {10.3389/fspor.2021.684089},
      url          = {https://pub.dzne.de/record/164211},
}