%0 Journal Article
%A Brugger, Manuel S
%A Baumgartner, Kathrin
%A Mauritz, Sophie C F
%A Gerlach, Stefan C
%A Röder, Florian
%A Schlosser, Christine
%A Fluhrer, Regina
%A Wixforth, Achim
%A Westerhausen, Christoph
%T Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model.
%J Proceedings of the National Academy of Sciences of the United States of America
%V 117
%N 50
%@ 0027-8424
%C Washington, DC
%I National Acad. of Sciences
%M DZNE-2022-00936
%P 31603 - 31613
%D 2020
%X We report on in vitro wound-healing and cell-growth studies under the influence of radio-frequency (rf) cell stimuli. These stimuli are supplied either by piezoactive surface acoustic waves (SAWs) or by microelectrode-generated electric fields, both at frequencies around 100 MHz. Employing live-cell imaging, we studied the time- and power-dependent healing of artificial wounds on a piezoelectric chip for different cell lines. If the cell stimulation is mediated by piezomechanical SAWs, we observe a pronounced, significant maximum of the cell-growth rate at a specific SAW amplitude, resulting in an increase of the wound-healing speed of up to 135 ± 85
%K Acoustic Stimulation: adverse effects
%K Acoustic Stimulation: instrumentation
%K Acoustic Stimulation: methods
%K Animals
%K Cell Line
%K Cell Line, Tumor
%K Cell Movement: radiation effects
%K Cell Proliferation: radiation effects
%K Combined Modality Therapy: adverse effects
%K Combined Modality Therapy: instrumentation
%K Combined Modality Therapy: methods
%K Dogs
%K Electrodes
%K Humans
%K Madin Darby Canine Kidney Cells
%K Oxidative Stress: drug effects
%K Reactive Oxygen Species
%K Sound: adverse effects
%K Vibration: therapeutic use
%K Wound Healing: radiation effects
%K cell growth (Other)
%K cell migration (Other)
%K stimulation (Other)
%K surface acoustic waves (Other)
%K vibration (Other)
%K Reactive Oxygen Species (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33257581
%2 pmc:PMC7749343
%R 10.1073/pnas.2005203117
%U https://pub.dzne.de/record/164282