TY  - JOUR
AU  - Brugger, Manuel S
AU  - Baumgartner, Kathrin
AU  - Mauritz, Sophie C F
AU  - Gerlach, Stefan C
AU  - Röder, Florian
AU  - Schlosser, Christine
AU  - Fluhrer, Regina
AU  - Wixforth, Achim
AU  - Westerhausen, Christoph
TI  - Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model.
JO  - Proceedings of the National Academy of Sciences of the United States of America
VL  - 117
IS  - 50
SN  - 0027-8424
CY  - Washington, DC
PB  - National Acad. of Sciences
M1  - DZNE-2022-00936
SP  - 31603 - 31613
PY  - 2020
AB  - We report on in vitro wound-healing and cell-growth studies under the influence of radio-frequency (rf) cell stimuli. These stimuli are supplied either by piezoactive surface acoustic waves (SAWs) or by microelectrode-generated electric fields, both at frequencies around 100 MHz. Employing live-cell imaging, we studied the time- and power-dependent healing of artificial wounds on a piezoelectric chip for different cell lines. If the cell stimulation is mediated by piezomechanical SAWs, we observe a pronounced, significant maximum of the cell-growth rate at a specific SAW amplitude, resulting in an increase of the wound-healing speed of up to 135 ± 85
KW  - Acoustic Stimulation: adverse effects
KW  - Acoustic Stimulation: instrumentation
KW  - Acoustic Stimulation: methods
KW  - Animals
KW  - Cell Line
KW  - Cell Line, Tumor
KW  - Cell Movement: radiation effects
KW  - Cell Proliferation: radiation effects
KW  - Combined Modality Therapy: adverse effects
KW  - Combined Modality Therapy: instrumentation
KW  - Combined Modality Therapy: methods
KW  - Dogs
KW  - Electrodes
KW  - Humans
KW  - Madin Darby Canine Kidney Cells
KW  - Oxidative Stress: drug effects
KW  - Reactive Oxygen Species
KW  - Sound: adverse effects
KW  - Vibration: therapeutic use
KW  - Wound Healing: radiation effects
KW  - cell growth (Other)
KW  - cell migration (Other)
KW  - stimulation (Other)
KW  - surface acoustic waves (Other)
KW  - vibration (Other)
KW  - Reactive Oxygen Species (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:33257581
C2  - pmc:PMC7749343
DO  - DOI:10.1073/pnas.2005203117
UR  - https://pub.dzne.de/record/164282
ER  -