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001     164282
005     20250717160443.0
024 7 _ |a 10.1073/pnas.2005203117
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037 _ _ |a DZNE-2022-00936
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Brugger, Manuel S
|0 0000-0002-9803-9127
|b 0
245 _ _ |a Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model.
260 _ _ |a Washington, DC
|c 2020
|b National Acad. of Sciences
336 7 _ |a article
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520 _ _ |a We report on in vitro wound-healing and cell-growth studies under the influence of radio-frequency (rf) cell stimuli. These stimuli are supplied either by piezoactive surface acoustic waves (SAWs) or by microelectrode-generated electric fields, both at frequencies around 100 MHz. Employing live-cell imaging, we studied the time- and power-dependent healing of artificial wounds on a piezoelectric chip for different cell lines. If the cell stimulation is mediated by piezomechanical SAWs, we observe a pronounced, significant maximum of the cell-growth rate at a specific SAW amplitude, resulting in an increase of the wound-healing speed of up to 135 ± 85% as compared to an internal reference. In contrast, cells being stimulated only by electrical fields of the same magnitude as the ones exposed to SAWs exhibit no significant effect. In this study, we investigate this effect for different wavelengths, amplitude modulation of the applied electrical rf signal, and different wave modes. Furthermore, to obtain insight into the biological response to the stimulus, we also determined both the cell-proliferation rate and the cellular stress levels. While the proliferation rate is significantly increased for a wide power range, cell stress remains low and within the normal range. Our findings demonstrate that SAW-based vibrational cell stimulation bears the potential for an alternative method to conventional ultrasound treatment, overcoming some of its limitations.
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650 _ 7 |a cell growth
|2 Other
650 _ 7 |a cell migration
|2 Other
650 _ 7 |a stimulation
|2 Other
650 _ 7 |a surface acoustic waves
|2 Other
650 _ 7 |a vibration
|2 Other
650 _ 7 |a Reactive Oxygen Species
|2 NLM Chemicals
650 _ 2 |a Acoustic Stimulation: adverse effects
|2 MeSH
650 _ 2 |a Acoustic Stimulation: instrumentation
|2 MeSH
650 _ 2 |a Acoustic Stimulation: methods
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cell Line
|2 MeSH
650 _ 2 |a Cell Line, Tumor
|2 MeSH
650 _ 2 |a Cell Movement: radiation effects
|2 MeSH
650 _ 2 |a Cell Proliferation: radiation effects
|2 MeSH
650 _ 2 |a Combined Modality Therapy: adverse effects
|2 MeSH
650 _ 2 |a Combined Modality Therapy: instrumentation
|2 MeSH
650 _ 2 |a Combined Modality Therapy: methods
|2 MeSH
650 _ 2 |a Dogs
|2 MeSH
650 _ 2 |a Electrodes
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Madin Darby Canine Kidney Cells
|2 MeSH
650 _ 2 |a Oxidative Stress: drug effects
|2 MeSH
650 _ 2 |a Reactive Oxygen Species
|2 MeSH
650 _ 2 |a Sound: adverse effects
|2 MeSH
650 _ 2 |a Vibration: therapeutic use
|2 MeSH
650 _ 2 |a Wound Healing: radiation effects
|2 MeSH
700 1 _ |a Baumgartner, Kathrin
|0 0000-0002-7008-9739
|b 1
700 1 _ |a Mauritz, Sophie C F
|b 2
700 1 _ |a Gerlach, Stefan C
|0 0000-0002-2477-0822
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700 1 _ |a Röder, Florian
|b 4
700 1 _ |a Schlosser, Christine
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700 1 _ |a Fluhrer, Regina
|0 P:(DE-2719)2000007
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700 1 _ |a Wixforth, Achim
|0 0000-0002-9399-9946
|b 7
700 1 _ |a Westerhausen, Christoph
|0 0000-0001-7103-7060
|b 8
773 _ _ |a 10.1073/pnas.2005203117
|g Vol. 117, no. 50, p. 31603 - 31613
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|t Proceedings of the National Academy of Sciences of the United States of America
|v 117
|y 2020
|x 0027-8424
856 4 _ |u https://pub.dzne.de/record/164282/files/DZNE-2022-00936_Restricted.pdf
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