%0 Journal Article
%A Scheumann, Vincent
%A Schreiber, Frank
%A Perosa, Valentina
%A Assmann, Anne
%A Mawrin, Christian
%A Garz, Cornelia
%A Heinze, Hans-Jochen
%A Görtler, Michael
%A Düzel, Emrah
%A Vielhaber, Stefan
%A Charidimou, Andreas
%A Schreiber, Stefanie
%T MRI phenotyping of underlying cerebral small vessel disease in mixed hemorrhage patients.
%J Journal of the neurological sciences
%V 419
%@ 0022-510X
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2022-00937
%P 117173
%D 2020
%X To investigate underlying cerebral small vessel disease (CSVD) in patients with mixed cerebral hemorrhages patterns and phenotype them according to the contribution of the two most common sporadic CSVD subtypes: cerebral amyloid angiopathy (CAA) vs. hypertensive arteriopathy (HA).Brain MRIs of patients with intracerebral hemorrhages (ICHs) and/or cerebral microbleeds (CMBs) were assessed for the full spectrum of CSVD markers using validated scales: ICHs, CMBs, cortical superficial siderosis (cSS), white matter hyperintensities, MRI-visible perivascular spaces (PVS). PVS predominance pattern was grouped as centrum-semiovale (CSO)-PVS predominance, basal-ganglia (BG)-PVS predominance, CSO-PVS and BG-PVS equality. Patients with mixed cerebral hemorrhages were classified into mixed CAA-pattern or mixed HA-pattern according to the existence of cSS and/or a CSO-PVS predominance pattern and comparisons were performed.We included 110 patients with CAA (strictly lobar ICHs/CMBs), 33 with HA (strictly deep ICHs/CMBs) and 97 with mixed lobar/deep ICHs/CMBs. Mixed patients were more similar to HA with respect to their MRI-CSVD markers, vascular risk profile and cerebrospinal fluid (CSF) measures. In the mixed patients, 33 (34
%K Cerebral Amyloid Angiopathy
%K Cerebral Hemorrhage: complications
%K Cerebral Hemorrhage: diagnostic imaging
%K Cerebral Small Vessel Diseases: complications
%K Cerebral Small Vessel Diseases: diagnostic imaging
%K Humans
%K Magnetic Resonance Imaging
%K Siderosis
%K Cerebral amyloid angiopathy (Other)
%K Cerebral small vessel diseases (Other)
%K Cerebrospinal fluid (Other)
%K Intracerebral hemorrhage (Other)
%K MRI (Other)
%K Vascular dementia (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33068905
%R 10.1016/j.jns.2020.117173
%U https://pub.dzne.de/record/164283