TY  - JOUR
AU  - Scheumann, Vincent
AU  - Schreiber, Frank
AU  - Perosa, Valentina
AU  - Assmann, Anne
AU  - Mawrin, Christian
AU  - Garz, Cornelia
AU  - Heinze, Hans-Jochen
AU  - Görtler, Michael
AU  - Düzel, Emrah
AU  - Vielhaber, Stefan
AU  - Charidimou, Andreas
AU  - Schreiber, Stefanie
TI  - MRI phenotyping of underlying cerebral small vessel disease in mixed hemorrhage patients.
JO  - Journal of the neurological sciences
VL  - 419
SN  - 0022-510X
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2022-00937
SP  - 117173
PY  - 2020
AB  - To investigate underlying cerebral small vessel disease (CSVD) in patients with mixed cerebral hemorrhages patterns and phenotype them according to the contribution of the two most common sporadic CSVD subtypes: cerebral amyloid angiopathy (CAA) vs. hypertensive arteriopathy (HA).Brain MRIs of patients with intracerebral hemorrhages (ICHs) and/or cerebral microbleeds (CMBs) were assessed for the full spectrum of CSVD markers using validated scales: ICHs, CMBs, cortical superficial siderosis (cSS), white matter hyperintensities, MRI-visible perivascular spaces (PVS). PVS predominance pattern was grouped as centrum-semiovale (CSO)-PVS predominance, basal-ganglia (BG)-PVS predominance, CSO-PVS and BG-PVS equality. Patients with mixed cerebral hemorrhages were classified into mixed CAA-pattern or mixed HA-pattern according to the existence of cSS and/or a CSO-PVS predominance pattern and comparisons were performed.We included 110 patients with CAA (strictly lobar ICHs/CMBs), 33 with HA (strictly deep ICHs/CMBs) and 97 with mixed lobar/deep ICHs/CMBs. Mixed patients were more similar to HA with respect to their MRI-CSVD markers, vascular risk profile and cerebrospinal fluid (CSF) measures. In the mixed patients, 33 (34
KW  - Cerebral Amyloid Angiopathy
KW  - Cerebral Hemorrhage: complications
KW  - Cerebral Hemorrhage: diagnostic imaging
KW  - Cerebral Small Vessel Diseases: complications
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Siderosis
KW  - Cerebral amyloid angiopathy (Other)
KW  - Cerebral small vessel diseases (Other)
KW  - Cerebrospinal fluid (Other)
KW  - Intracerebral hemorrhage (Other)
KW  - MRI (Other)
KW  - Vascular dementia (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33068905
DO  - DOI:10.1016/j.jns.2020.117173
UR  - https://pub.dzne.de/record/164283
ER  -