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@ARTICLE{Scheumann:164283,
      author       = {Scheumann, Vincent and Schreiber, Frank and Perosa,
                      Valentina and Assmann, Anne and Mawrin, Christian and Garz,
                      Cornelia and Heinze, Hans-Jochen and Görtler, Michael and
                      Düzel, Emrah and Vielhaber, Stefan and Charidimou, Andreas
                      and Schreiber, Stefanie},
      title        = {{MRI} phenotyping of underlying cerebral small vessel
                      disease in mixed hemorrhage patients.},
      journal      = {Journal of the neurological sciences},
      volume       = {419},
      issn         = {0022-510X},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2022-00937},
      pages        = {117173},
      year         = {2020},
      abstract     = {To investigate underlying cerebral small vessel disease
                      (CSVD) in patients with mixed cerebral hemorrhages patterns
                      and phenotype them according to the contribution of the two
                      most common sporadic CSVD subtypes: cerebral amyloid
                      angiopathy (CAA) vs. hypertensive arteriopathy (HA).Brain
                      MRIs of patients with intracerebral hemorrhages (ICHs)
                      and/or cerebral microbleeds (CMBs) were assessed for the
                      full spectrum of CSVD markers using validated scales: ICHs,
                      CMBs, cortical superficial siderosis (cSS), white matter
                      hyperintensities, MRI-visible perivascular spaces (PVS). PVS
                      predominance pattern was grouped as centrum-semiovale
                      (CSO)-PVS predominance, basal-ganglia (BG)-PVS predominance,
                      CSO-PVS and BG-PVS equality. Patients with mixed cerebral
                      hemorrhages were classified into mixed CAA-pattern or mixed
                      HA-pattern according to the existence of cSS and/or a
                      CSO-PVS predominance pattern and comparisons were
                      performed.We included 110 patients with CAA (strictly lobar
                      ICHs/CMBs), 33 with HA (strictly deep ICHs/CMBs) and 97 with
                      mixed lobar/deep ICHs/CMBs. Mixed patients were more similar
                      to HA with respect to their MRI-CSVD markers, vascular risk
                      profile and cerebrospinal fluid (CSF) measures. In the mixed
                      patients, 33 $(34\%)$ had cSS, a CSO-PVS predominance
                      pattern, or both, and were defined as mixed CAA-pattern
                      cases. The mixed CAA-pattern patients were more alike CAA
                      patients regarding their MRI-CSVD markers, CSF and genetic
                      profile.Our findings suggest that the heterogeneous group of
                      patients with mixed cerebral hemorrhages distribution can be
                      further phenotyped according to the predominant underlying
                      CSVD. cSS presence and a CSO-PVS predominance pattern could
                      serve as strongly suggestive markers of a contribution from
                      CAA among patients with mixed hemorrhages.},
      keywords     = {Cerebral Amyloid Angiopathy / Cerebral Hemorrhage:
                      complications / Cerebral Hemorrhage: diagnostic imaging /
                      Cerebral Small Vessel Diseases: complications / Cerebral
                      Small Vessel Diseases: diagnostic imaging / Humans /
                      Magnetic Resonance Imaging / Siderosis / Cerebral amyloid
                      angiopathy (Other) / Cerebral small vessel diseases (Other)
                      / Cerebrospinal fluid (Other) / Intracerebral hemorrhage
                      (Other) / MRI (Other) / Vascular dementia (Other)},
      cin          = {U Clinical Researchers - Magdeburg / AG Düzel / AG Reymann
                      / AG Schreiber},
      ddc          = {610},
      cid          = {I:(DE-2719)7000000 / I:(DE-2719)5000006 /
                      I:(DE-2719)1310005 / I:(DE-2719)1310010},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33068905},
      doi          = {10.1016/j.jns.2020.117173},
      url          = {https://pub.dzne.de/record/164283},
}