%0 Journal Article
%A Spijker, Sabine
%A Koskinen, Maija-Kreetta
%A Riga, Danai
%T Incubation of depression: ECM assembly and parvalbumin interneurons after stress.
%J Neuroscience & biobehavioral reviews
%V 118
%@ 0149-7634
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2022-00979
%P 65 - 79
%D 2020
%Z (CC-BY 4.0)
%X The extracellular space is occupied by a complex network of proteins creating a mesh-like assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like structures, perineuronal nets (PNNs), that envelope cell somas and proximal neurites of predominantly parvalbumin+-(PV+) interneurons. ECM regulates cell-to-cell communication, thereby modulating neuronal network function. Accumulating evidence points to the importance of network dysfunction in the pathophysiology of psychiatric diseases, in which stress acts as a major predisposing factor. Here we review stress-induced changes in ECM/PNNs and PV+-interneurons in preclinical models of (or for) depression, with a special focus on social stress. We argue that the direction of these alterations largely depends on stress recency, as well as on stress timing and the brain region under investigation. A biphasic temporal regulation of ECM/PNNs and PV+-interneuron function is typically observed after stress. Understanding the complex mechanisms underlying ECM organization in relation to stress-induced molecular, cellular and network changes is crucial to further decipher the implications of ECM remodeling in the incubation of depressive symptoms.
%K Depression
%K Extracellular Matrix
%K Interneurons
%K Neurons
%K Parvalbumins
%K Chronic mild/unpredictable stress (Other)
%K Early life stress (Other)
%K Experience-dependent plasticity (Other)
%K Hippocampus (Other)
%K Hyper-excitability (Other)
%K Hypo-excitability (Other)
%K Prefrontal cortex (Other)
%K Restraint stress (Other)
%K Social defeat stress (Other)
%K Parvalbumins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32687884
%R 10.1016/j.neubiorev.2020.07.015
%U https://pub.dzne.de/record/164427