TY  - JOUR
AU  - Spijker, Sabine
AU  - Koskinen, Maija-Kreetta
AU  - Riga, Danai
TI  - Incubation of depression: ECM assembly and parvalbumin interneurons after stress.
JO  - Neuroscience & biobehavioral reviews
VL  - 118
SN  - 0149-7634
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2022-00979
SP  - 65 - 79
PY  - 2020
N1  - (CC-BY 4.0)
AB  - The extracellular space is occupied by a complex network of proteins creating a mesh-like assembly known as the extracellular matrix (ECM). ECM assembles into dense net-like structures, perineuronal nets (PNNs), that envelope cell somas and proximal neurites of predominantly parvalbumin+-(PV+) interneurons. ECM regulates cell-to-cell communication, thereby modulating neuronal network function. Accumulating evidence points to the importance of network dysfunction in the pathophysiology of psychiatric diseases, in which stress acts as a major predisposing factor. Here we review stress-induced changes in ECM/PNNs and PV+-interneurons in preclinical models of (or for) depression, with a special focus on social stress. We argue that the direction of these alterations largely depends on stress recency, as well as on stress timing and the brain region under investigation. A biphasic temporal regulation of ECM/PNNs and PV+-interneuron function is typically observed after stress. Understanding the complex mechanisms underlying ECM organization in relation to stress-induced molecular, cellular and network changes is crucial to further decipher the implications of ECM remodeling in the incubation of depressive symptoms.
KW  - Depression
KW  - Extracellular Matrix
KW  - Interneurons
KW  - Neurons
KW  - Parvalbumins
KW  - Chronic mild/unpredictable stress (Other)
KW  - Early life stress (Other)
KW  - Experience-dependent plasticity (Other)
KW  - Hippocampus (Other)
KW  - Hyper-excitability (Other)
KW  - Hypo-excitability (Other)
KW  - Prefrontal cortex (Other)
KW  - Restraint stress (Other)
KW  - Social defeat stress (Other)
KW  - Parvalbumins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:32687884
DO  - DOI:10.1016/j.neubiorev.2020.07.015
UR  - https://pub.dzne.de/record/164427
ER  -