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@ARTICLE{Spijker:164427,
      author       = {Spijker, Sabine and Koskinen, Maija-Kreetta and Riga,
                      Danai},
      title        = {{I}ncubation of depression: {ECM} assembly and parvalbumin
                      interneurons after stress.},
      journal      = {Neuroscience $\&$ biobehavioral reviews},
      volume       = {118},
      issn         = {0149-7634},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2022-00979},
      pages        = {65 - 79},
      year         = {2020},
      note         = {(CC-BY 4.0)},
      abstract     = {The extracellular space is occupied by a complex network of
                      proteins creating a mesh-like assembly known as the
                      extracellular matrix (ECM). ECM assembles into dense
                      net-like structures, perineuronal nets (PNNs), that envelope
                      cell somas and proximal neurites of predominantly
                      parvalbumin+-(PV+) interneurons. ECM regulates cell-to-cell
                      communication, thereby modulating neuronal network function.
                      Accumulating evidence points to the importance of network
                      dysfunction in the pathophysiology of psychiatric diseases,
                      in which stress acts as a major predisposing factor. Here we
                      review stress-induced changes in ECM/PNNs and
                      PV+-interneurons in preclinical models of (or for)
                      depression, with a special focus on social stress. We argue
                      that the direction of these alterations largely depends on
                      stress recency, as well as on stress timing and the brain
                      region under investigation. A biphasic temporal regulation
                      of ECM/PNNs and PV+-interneuron function is typically
                      observed after stress. Understanding the complex mechanisms
                      underlying ECM organization in relation to stress-induced
                      molecular, cellular and network changes is crucial to
                      further decipher the implications of ECM remodeling in the
                      incubation of depressive symptoms.},
      subtyp        = {Review Article},
      keywords     = {Depression / Extracellular Matrix / Interneurons / Neurons
                      / Parvalbumins / Chronic mild/unpredictable stress (Other) /
                      Early life stress (Other) / Experience-dependent plasticity
                      (Other) / Hippocampus (Other) / Hyper-excitability (Other) /
                      Hypo-excitability (Other) / Prefrontal cortex (Other) /
                      Restraint stress (Other) / Social defeat stress (Other) /
                      Parvalbumins (NLM Chemicals)},
      cin          = {AG Dityatev},
      ddc          = {610},
      cid          = {I:(DE-2719)1310007},
      pnm          = {899 - ohne Topic (POF4-899)},
      pid          = {G:(DE-HGF)POF4-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32687884},
      doi          = {10.1016/j.neubiorev.2020.07.015},
      url          = {https://pub.dzne.de/record/164427},
}