TY  - JOUR
AU  - Lauwers, Elsa
AU  - Lalli, Giovanna
AU  - Brandner, Sebastian
AU  - Collinge, John
AU  - Compernolle, Veerle
AU  - Duyckaerts, Charles
AU  - Edgren, Gustaf
AU  - Haïk, Stéphane
AU  - Hardy, John
AU  - Helmy, Adel
AU  - Ivinson, Adrian J
AU  - Jaunmuktane, Zane
AU  - Jucker, Mathias
AU  - Knight, Richard
AU  - Lemmens, Robin
AU  - Lin, I-Chun
AU  - Love, Seth
AU  - Mead, Simon
AU  - Perry, V Hugh
AU  - Pickett, James
AU  - Poppy, Guy
AU  - Radford, Sheena E
AU  - Rousseau, Frederic
AU  - Routledge, Carol
AU  - Schiavo, Giampietro
AU  - Schymkowitz, Joost
AU  - Selkoe, Dennis J
AU  - Smith, Colin
AU  - Thal, Dietmar R
AU  - Theys, Tom
AU  - Tiberghien, Pierre
AU  - van den Burg, Peter
AU  - Vandekerckhove, Philippe
AU  - Walton, Clare
AU  - Zaaijer, Hans L
AU  - Zetterberg, Henrik
AU  - De Strooper, Bart
TI  - Potential human transmission of amyloid β pathology: surveillance and risks
JO  - The lancet  / Neurology
VL  - 19
IS  - 10
SN  - 1474-4422
CY  - London
PB  - Lancet Publ. Group
M1  - DZNE-2022-00981
SP  - 872 - 878
PY  - 2020
AB  - Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, convincing evidence for human iatrogenic transmission only exists for prions and amyloid β after systemic injections of contaminated growth hormone extracts or dura mater grafts derived from cadavers. Even though these procedures are now obsolete, some reports raise the possibility of iatrogenic transmission of amyloid β through putatively contaminated neurosurgical equipment. Iatrogenic transmission of amyloid β might lead to amyloid deposition in the brain parenchyma and blood vessel walls, potentially resulting in cerebral amyloid angiopathy after several decades. Cerebral amyloid angiopathy can cause life-threatening brain haemorrhages; yet, there is no proof that the transmission of amyloid β can also lead to Alzheimer's dementia. Large, long-term epidemiological studies and sensitive, cost-efficient tools to detect amyloid are needed to better understand any potential routes of amyloid β transmission and to clarify whether other similar proteopathic seeds, such as tau or α-synuclein, can also be transferred iatrogenically.
KW  - Alzheimer Disease: etiology
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Amyloid beta-Peptides: metabolism
KW  - Amyloid beta-Peptides: toxicity
KW  - Animals
KW  - Creutzfeldt-Jakob Syndrome: metabolism
KW  - Creutzfeldt-Jakob Syndrome: pathology
KW  - Creutzfeldt-Jakob Syndrome: transmission
KW  - Humans
KW  - Neurodegenerative Diseases: etiology
KW  - Neurodegenerative Diseases: metabolism
KW  - Neurodegenerative Diseases: pathology
KW  - Parkinson Disease: etiology
KW  - Parkinson Disease: metabolism
KW  - Parkinson Disease: pathology
KW  - Population Surveillance
KW  - Risk Factors
LB  - PUB:(DE-HGF)16
C6  - pmid:32949547
DO  - DOI:10.1016/S1474-4422(20)30238-6
UR  - https://pub.dzne.de/record/164429
ER  -