TY  - JOUR
AU  - Traub, Jan
AU  - Otto, Markus
AU  - Sell, Roxane
AU  - Homola, György A
AU  - Steinacker, Petra
AU  - Oeckl, Patrick
AU  - Morbach, Caroline
AU  - Frantz, Stefan
AU  - Pham, Mirko
AU  - Störk, Stefan
AU  - Stoll, Guido
AU  - Frey, Anna
TI  - Serum glial fibrillary acidic protein indicates memory impairment in patients with chronic heart failure.
JO  - ESC heart failure
VL  - 9
IS  - 4
SN  - 2055-5822
CY  - Chichester
PB  - Wiley
M1  - DZNE-2022-01083
SP  - 2626-2634
PY  - 2022
AB  - Cognitive dysfunction occurs frequently in patients with heart failure (HF), but early detection remains challenging. Serum glial fibrillary acidic protein (GFAP) is an emerging biomarker of cognitive decline in disorders of primary neurodegeneration such as Alzheimer's disease. We evaluated the utility of serum GFAP as a biomarker for cognitive dysfunction and structural brain damage in patients with stable chronic HF.Using bead-based single molecule immunoassays, we quantified serum levels of GFAP in patients with HF participating in the prospective Cognition.Matters-HF study. Participants were extensively phenotyped, including cognitive testing of five separate domains and magnetic resonance imaging (MRI) of the brain. Univariable and multivariable models, also accounting for multiple testing, were run. One hundred and forty-six chronic HF patients with a mean age of 63.8 ± 10.8 years were included (15.1
KW  - Aged
KW  - Atrophy
KW  - Biomarkers
KW  - Female
KW  - Glial Fibrillary Acidic Protein: metabolism
KW  - Heart Failure: complications
KW  - Heart Failure: diagnosis
KW  - Humans
KW  - Male
KW  - Memory Disorders: diagnosis
KW  - Memory Disorders: etiology
KW  - Middle Aged
KW  - Prospective Studies
KW  - Brain atrophy (Other)
KW  - Chronic heart failure (Other)
KW  - Cognitive decline (Other)
KW  - GFAP (Other)
KW  - Glial fibrillary acidic protein (Other)
KW  - Memory dysfunction (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9288738
C6  - pmid:35611842
DO  - DOI:10.1002/ehf2.13986
UR  - https://pub.dzne.de/record/164534
ER  -