%0 Journal Article
%A Endres, Dominique
%A von Zedtwitz, Katharina
%A Matteit, Isabelle
%A Bünger, Isabel
%A Foverskov Rasmussen, Helle
%A Runge, Kimon
%A Feige, Bernd
%A Schlump, Andrea
%A Maier, Simon
%A Nickel, Kathrin
%A Berger, Benjamin
%A Schiele, Miriam A.
%A Cunningham, Janet L.
%A Domschke, Katharina
%A Prüß, Harald
%A Tebartz van Elst, Ludger
%T Spectrum of Novel Anti–Central Nervous System Autoantibodies in the Cerebrospinal Fluid of 119 Patients With Schizophreniform and Affective Disorders
%J Biological psychiatry
%V 92
%N 4
%@ 0006-3223
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2022-01094
%P 261-274
%D 2022
%X Autoimmune psychosis may be caused by well-characterized anti-neuronal autoantibodies, such as those against the NMDA receptor. However, the presence of additional anti–central nervous system (CNS) autoantibodies in these patients has not been systematically assessed.MethodsSerum and cerebrospinal fluid (CSF) from patients with schizophreniform and affective syndromes were analyzed for immunoglobulin G anti-CNS autoantibodies using tissue-based assays with indirect immunofluorescence on unfixed murine brain tissue as part of an extended routine clinical practice. After an initial assessment of patients with red flags for autoimmune psychosis (n = 30), tissue-based testing was extended to a routine procedure (n = 89).ResultsBased on the findings from all 119 patients, anti-CNS immunoglobulin G autoantibodies against brain tissue were detected in 18
%K Animals
%K Autoantibodies
%K Brain
%K Endothelial Cells
%K Granulocyte-Macrophage Colony-Stimulating Factor
%K Humans
%K Immunoglobulin G
%K Mice
%K Mood Disorders
%K Anti-neuronal autoantibody (Other)
%K Autoantibody (Other)
%K Autoimmune psychosis (Other)
%K Blood-brain barrier (Other)
%K Cerebrospinal fluid (Other)
%K Endothelial cells (Other)
%K Granule cells (Other)
%K Schizophrenia (Other)
%K Autoantibodies (NLM Chemicals)
%K Immunoglobulin G (NLM Chemicals)
%K Granulocyte-Macrophage Colony-Stimulating Factor (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35606187
%R 10.1016/j.biopsych.2022.02.010
%U https://pub.dzne.de/record/164545