TY  - JOUR
AU  - Endres, Dominique
AU  - von Zedtwitz, Katharina
AU  - Matteit, Isabelle
AU  - Bünger, Isabel
AU  - Foverskov Rasmussen, Helle
AU  - Runge, Kimon
AU  - Feige, Bernd
AU  - Schlump, Andrea
AU  - Maier, Simon
AU  - Nickel, Kathrin
AU  - Berger, Benjamin
AU  - Schiele, Miriam A.
AU  - Cunningham, Janet L.
AU  - Domschke, Katharina
AU  - Prüß, Harald
AU  - Tebartz van Elst, Ludger
TI  - Spectrum of Novel Anti–Central Nervous System Autoantibodies in the Cerebrospinal Fluid of 119 Patients With Schizophreniform and Affective Disorders
JO  - Biological psychiatry
VL  - 92
IS  - 4
SN  - 0006-3223
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2022-01094
SP  - 261-274
PY  - 2022
AB  - Autoimmune psychosis may be caused by well-characterized anti-neuronal autoantibodies, such as those against the NMDA receptor. However, the presence of additional anti–central nervous system (CNS) autoantibodies in these patients has not been systematically assessed.MethodsSerum and cerebrospinal fluid (CSF) from patients with schizophreniform and affective syndromes were analyzed for immunoglobulin G anti-CNS autoantibodies using tissue-based assays with indirect immunofluorescence on unfixed murine brain tissue as part of an extended routine clinical practice. After an initial assessment of patients with red flags for autoimmune psychosis (n = 30), tissue-based testing was extended to a routine procedure (n = 89).ResultsBased on the findings from all 119 patients, anti-CNS immunoglobulin G autoantibodies against brain tissue were detected in 18
KW  - Animals
KW  - Autoantibodies
KW  - Brain
KW  - Endothelial Cells
KW  - Granulocyte-Macrophage Colony-Stimulating Factor
KW  - Humans
KW  - Immunoglobulin G
KW  - Mice
KW  - Mood Disorders
KW  - Anti-neuronal autoantibody (Other)
KW  - Autoantibody (Other)
KW  - Autoimmune psychosis (Other)
KW  - Blood-brain barrier (Other)
KW  - Cerebrospinal fluid (Other)
KW  - Endothelial cells (Other)
KW  - Granule cells (Other)
KW  - Schizophrenia (Other)
KW  - Autoantibodies (NLM Chemicals)
KW  - Immunoglobulin G (NLM Chemicals)
KW  - Granulocyte-Macrophage Colony-Stimulating Factor (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:35606187
DO  - DOI:10.1016/j.biopsych.2022.02.010
UR  - https://pub.dzne.de/record/164545
ER  -