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@ARTICLE{Endres:164545,
      author       = {Endres, Dominique and von Zedtwitz, Katharina and Matteit,
                      Isabelle and Bünger, Isabel and Foverskov Rasmussen, Helle
                      and Runge, Kimon and Feige, Bernd and Schlump, Andrea and
                      Maier, Simon and Nickel, Kathrin and Berger, Benjamin and
                      Schiele, Miriam A. and Cunningham, Janet L. and Domschke,
                      Katharina and Prüß, Harald and Tebartz van Elst, Ludger},
      title        = {{S}pectrum of {N}ovel {A}nti–{C}entral {N}ervous {S}ystem
                      {A}utoantibodies in the {C}erebrospinal {F}luid of 119
                      {P}atients {W}ith {S}chizophreniform and {A}ffective
                      {D}isorders},
      journal      = {Biological psychiatry},
      volume       = {92},
      number       = {4},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2022-01094},
      pages        = {261-274},
      year         = {2022},
      abstract     = {Autoimmune psychosis may be caused by well-characterized
                      anti-neuronal autoantibodies, such as those against the NMDA
                      receptor. However, the presence of additional anti–central
                      nervous system (CNS) autoantibodies in these patients has
                      not been systematically assessed.MethodsSerum and
                      cerebrospinal fluid (CSF) from patients with
                      schizophreniform and affective syndromes were analyzed for
                      immunoglobulin G anti-CNS autoantibodies using tissue-based
                      assays with indirect immunofluorescence on unfixed murine
                      brain tissue as part of an extended routine clinical
                      practice. After an initial assessment of patients with red
                      flags for autoimmune psychosis (n = 30), tissue-based
                      testing was extended to a routine procedure (n =
                      89).ResultsBased on the findings from all 119 patients,
                      anti-CNS immunoglobulin G autoantibodies against brain
                      tissue were detected in $18\%$ (n = 22) of patients (serum
                      $9\%,$ CSF $18\%)$ following five principal patterns: 1)
                      against vascular structures, most likely endothelial cells
                      (serum $3\%,$ CSF $8\%);$ 2) against granule cells in the
                      cerebellum and/or hippocampus (serum $4\%,$ CSF $6\%);$ 3)
                      against myelinated fibers (serum $2\%,$ CSF $2\%);$ 4)
                      against cerebellar Purkinje cells (serum $0\%,$ CSF $2\%);$
                      and 5) against astrocytes (serum $1\%,$ CSF $1\%).$ The
                      patients with novel anti-CNS autoantibodies showed increased
                      albumin quotients (p = .026) and white matter changes (p =
                      .020) more frequently than those who tested negative for
                      autoantibodies.ConclusionsThe study demonstrates five novel
                      autoantibody-binding patterns on brain tissue of patients
                      with schizophreniform and affective syndromes. CSF yielded
                      positive findings more frequently than serum analysis. The
                      frequency and spectrum of autoantibodies in these patient
                      groups may be broader than previously thought.},
      keywords     = {Animals / Autoantibodies / Brain / Endothelial Cells /
                      Granulocyte-Macrophage Colony-Stimulating Factor / Humans /
                      Immunoglobulin G / Mice / Mood Disorders / Anti-neuronal
                      autoantibody (Other) / Autoantibody (Other) / Autoimmune
                      psychosis (Other) / Blood-brain barrier (Other) /
                      Cerebrospinal fluid (Other) / Endothelial cells (Other) /
                      Granule cells (Other) / Schizophrenia (Other) /
                      Autoantibodies (NLM Chemicals) / Immunoglobulin G (NLM
                      Chemicals) / Granulocyte-Macrophage Colony-Stimulating
                      Factor (NLM Chemicals)},
      cin          = {AG Prüß},
      ddc          = {610},
      cid          = {I:(DE-2719)1810003},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35606187},
      doi          = {10.1016/j.biopsych.2022.02.010},
      url          = {https://pub.dzne.de/record/164545},
}