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000164574 1001_ $$00000-0001-5846-7058$$aScuteri, Damiana$$b0
000164574 245__ $$aPharmacological Treatment of Pain and Agitation in Severe Dementia and Responsiveness to Change of the Italian Mobilization-Observation-Behavior-Intensity-Dementia (I-MOBID2) Pain Scale: Study Protocol.
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000164574 520__ $$aUp to 80% of Alzheimer's disease (AD) patients in nursing homes experiences chronic pain and 97% develops fluctuant neuropsychiatric symptoms (NPS). Agitation, associated with unrelieved pain, is managed through antipsychotics and may increase the risk of death. Evidence is accumulating in favor of analgesia for a safer, effective therapy of agitation. The Italian version of Mobilization-Observation-Behavior-Intensity-Dementia, I-MOBID2, recently validated in the Italian setting, shows: good scale content validity index (0.89), high construct validity (Spearman rank-order correlation Rho = 0.748), reliable internal consistency (Cronbach's α coefficient = 0.751), good-excellent inter-rater (intraclass correlation coefficient, ICC = 0.778) and test-retest (ICC = 0.902) reliability, and good inter-rater and test-retest agreement (Cohen's K = 0.744) with 5.8 min completion time. This study intends to identify the responsiveness of the I-MOBID2 based on COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations, assessing the a priori hypotheses of (1) the efficacy of painkillers administered to severe AD patients after proper pain assessment and (2) the effect of reduction of the Cohen-Mansfield Agitation Inventory (CMAI) score and of agitation rescue medications. This protocol is approved by Calabria Region Ethics Committee protocol No. 31/2017 and follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines.
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000164574 650_7 $$2Other$$aagitation
000164574 650_7 $$2Other$$adementia
000164574 650_7 $$2Other$$apain
000164574 650_7 $$2Other$$aresponsiveness
000164574 7001_ $$00000-0002-9825-1347$$aContrada, Marianna$$b1
000164574 7001_ $$aLoria, Teresa$$b2
000164574 7001_ $$00000-0002-4867-1378$$aTonin, Paolo$$b3
000164574 7001_ $$aSandrini, Giorgio$$b4
000164574 7001_ $$00000-0002-1561-2187$$aTamburin, Stefano$$b5
000164574 7001_ $$0P:(DE-2719)2010732$$aNicotera, Pierluigi$$b6$$udzne
000164574 7001_ $$00000-0001-8540-6218$$aBagetta, Giacinto$$b7
000164574 7001_ $$00000-0001-6472-0697$$aCorasaniti, Maria Tiziana$$b8
000164574 773__ $$0PERI:(DE-600)2651993-8$$a10.3390/brainsci12050573$$gVol. 12, no. 5, p. 573 -$$n5$$p573$$tBrain Sciences$$v12$$x2076-3425$$y2022
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