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@ARTICLE{Scuteri:164574,
      author       = {Scuteri, Damiana and Contrada, Marianna and Loria, Teresa
                      and Tonin, Paolo and Sandrini, Giorgio and Tamburin, Stefano
                      and Nicotera, Pierluigi and Bagetta, Giacinto and
                      Corasaniti, Maria Tiziana},
      title        = {{P}harmacological {T}reatment of {P}ain and {A}gitation in
                      {S}evere {D}ementia and {R}esponsiveness to {C}hange of the
                      {I}talian
                      {M}obilization-{O}bservation-{B}ehavior-{I}ntensity-{D}ementia
                      ({I}-{MOBID}2) {P}ain {S}cale: {S}tudy {P}rotocol.},
      journal      = {Brain Sciences},
      volume       = {12},
      number       = {5},
      issn         = {2076-3425},
      address      = {Basel},
      publisher    = {MDPI AG},
      reportid     = {DZNE-2022-01123},
      pages        = {573},
      year         = {2022},
      abstract     = {Up to $80\%$ of Alzheimer's disease (AD) patients in
                      nursing homes experiences chronic pain and $97\%$ develops
                      fluctuant neuropsychiatric symptoms (NPS). Agitation,
                      associated with unrelieved pain, is managed through
                      antipsychotics and may increase the risk of death. Evidence
                      is accumulating in favor of analgesia for a safer, effective
                      therapy of agitation. The Italian version of
                      Mobilization-Observation-Behavior-Intensity-Dementia,
                      I-MOBID2, recently validated in the Italian setting, shows:
                      good scale content validity index (0.89), high construct
                      validity (Spearman rank-order correlation Rho = 0.748),
                      reliable internal consistency (Cronbach's α coefficient =
                      0.751), good-excellent inter-rater (intraclass correlation
                      coefficient, ICC = 0.778) and test-retest (ICC = 0.902)
                      reliability, and good inter-rater and test-retest agreement
                      (Cohen's K = 0.744) with 5.8 min completion time. This study
                      intends to identify the responsiveness of the I-MOBID2 based
                      on COnsensus-based Standards for the selection of health
                      Measurement Instruments (COSMIN) recommendations, assessing
                      the a priori hypotheses of (1) the efficacy of painkillers
                      administered to severe AD patients after proper pain
                      assessment and (2) the effect of reduction of the
                      Cohen-Mansfield Agitation Inventory (CMAI) score and of
                      agitation rescue medications. This protocol is approved by
                      Calabria Region Ethics Committee protocol No. 31/2017 and
                      follows the Standard Protocol Items: Recommendations for
                      Interventional Trials (SPIRIT) guidelines.},
      keywords     = {I-MOBID2 (Other) / agitation (Other) / dementia (Other) /
                      pain (Other) / responsiveness (Other)},
      cin          = {Scientific board / AG Bano},
      ddc          = {570},
      cid          = {I:(DE-2719)1030000 / I:(DE-2719)1013003},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9139373},
      pubmed       = {pmid:35624960},
      doi          = {10.3390/brainsci12050573},
      url          = {https://pub.dzne.de/record/164574},
}