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| 024 | 7 | _ | |a 10.3390/brainsci12050573 |2 doi |
| 024 | 7 | _ | |a pmid:35624960 |2 pmid |
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| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Scuteri, Damiana |0 0000-0001-5846-7058 |b 0 |
| 245 | _ | _ | |a Pharmacological Treatment of Pain and Agitation in Severe Dementia and Responsiveness to Change of the Italian Mobilization-Observation-Behavior-Intensity-Dementia (I-MOBID2) Pain Scale: Study Protocol. |
| 260 | _ | _ | |a Basel |c 2022 |b MDPI AG |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1654779356_6361 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Up to 80% of Alzheimer's disease (AD) patients in nursing homes experiences chronic pain and 97% develops fluctuant neuropsychiatric symptoms (NPS). Agitation, associated with unrelieved pain, is managed through antipsychotics and may increase the risk of death. Evidence is accumulating in favor of analgesia for a safer, effective therapy of agitation. The Italian version of Mobilization-Observation-Behavior-Intensity-Dementia, I-MOBID2, recently validated in the Italian setting, shows: good scale content validity index (0.89), high construct validity (Spearman rank-order correlation Rho = 0.748), reliable internal consistency (Cronbach's α coefficient = 0.751), good-excellent inter-rater (intraclass correlation coefficient, ICC = 0.778) and test-retest (ICC = 0.902) reliability, and good inter-rater and test-retest agreement (Cohen's K = 0.744) with 5.8 min completion time. This study intends to identify the responsiveness of the I-MOBID2 based on COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) recommendations, assessing the a priori hypotheses of (1) the efficacy of painkillers administered to severe AD patients after proper pain assessment and (2) the effect of reduction of the Cohen-Mansfield Agitation Inventory (CMAI) score and of agitation rescue medications. This protocol is approved by Calabria Region Ethics Committee protocol No. 31/2017 and follows the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines. |
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| 650 | _ | 7 | |a I-MOBID2 |2 Other |
| 650 | _ | 7 | |a agitation |2 Other |
| 650 | _ | 7 | |a dementia |2 Other |
| 650 | _ | 7 | |a pain |2 Other |
| 650 | _ | 7 | |a responsiveness |2 Other |
| 700 | 1 | _ | |a Contrada, Marianna |0 0000-0002-9825-1347 |b 1 |
| 700 | 1 | _ | |a Loria, Teresa |b 2 |
| 700 | 1 | _ | |a Tonin, Paolo |0 0000-0002-4867-1378 |b 3 |
| 700 | 1 | _ | |a Sandrini, Giorgio |b 4 |
| 700 | 1 | _ | |a Tamburin, Stefano |0 0000-0002-1561-2187 |b 5 |
| 700 | 1 | _ | |a Nicotera, Pierluigi |0 P:(DE-2719)2010732 |b 6 |u dzne |
| 700 | 1 | _ | |a Bagetta, Giacinto |0 0000-0001-8540-6218 |b 7 |
| 700 | 1 | _ | |a Corasaniti, Maria Tiziana |0 0000-0001-6472-0697 |b 8 |
| 773 | _ | _ | |a 10.3390/brainsci12050573 |g Vol. 12, no. 5, p. 573 - |0 PERI:(DE-600)2651993-8 |n 5 |p 573 |t Brain Sciences |v 12 |y 2022 |x 2076-3425 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/164574/files/Pharmacological%20Treatment%20of%20Pain%20and%20Agitation%20in%20Severe%20Dementia%20and%20Responsiveness%20to%20Change%20of%20the%20Italian%20Mobilization%E2%80%93Observation%E2%80%93Behavior%E2%80%93Intensity%E2%80%93Dementia%20%28I-MOBID2%29%20Pain%20Scale%3A.pdf |
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| 914 | 1 | _ | |y 2022 |
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