%0 Journal Article
%A Schwarz, Claudia
%A Benson, Gloria S
%A Horn, Nora
%A Wurdack, Katharina
%A Grittner, Ulrike
%A Schilling, Ralph
%A Märschenz, Stefanie
%A Köbe, Theresa
%A Hofer, Sebastian J
%A Magnes, Christoph
%A Stekovic, Slaven
%A Eisenberg, Tobias
%A Sigrist, Stephan
%A Schmitz, Dietmar
%A Wirth, Miranka
%A Madeo, Frank
%A Flöel, Agnes
%T Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
%J JAMA network open
%V 5
%N 5
%@ 2574-3805
%C Chicago, Ill.
%I American Medical Association
%M DZNE-2022-01137
%P e2213875
%D 2022
%Z (CC BY)
%X Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one of the greatest challenges of our generation. Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline.To determine the effect of longer-term spermidine supplementation on memory performance and biomarkers in this at-risk group.This 12-month randomized, double-masked, placebo-controlled phase 2b trial (the SmartAge trial) was conducted between January 2017 and May 2020. The study was a monocenter trial carried out at an academic clinical research center in Germany. Eligible individuals were aged 60 to 90 years with subjective cognitive decline who were recruited from health care facilities as well as through advertisements in the general population. Data analysis was conducted between January and March 2021.One hundred participants were randomly assigned (1:1 ratio) to 12 months of dietary supplementation with either a spermidine-rich dietary supplement extracted from wheat germ (0.9 mg spermidine/d) or placebo (microcrystalline cellulose). Eighty-nine participants (89
%K Aged
%K Animals
%K Biomarkers
%K Cognition: physiology
%K Cognitive Dysfunction: drug therapy
%K Dietary Supplements
%K Female
%K Humans
%K Inflammation
%K Neurodegenerative Diseases
%K Spermidine: pharmacology
%K Spermidine: therapeutic use
%K Biomarkers (NLM Chemicals)
%K Spermidine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC9136623
%$ pmid:35616942
%R 10.1001/jamanetworkopen.2022.13875
%U https://pub.dzne.de/record/164588