TY  - JOUR
AU  - Schwarz, Claudia
AU  - Benson, Gloria S
AU  - Horn, Nora
AU  - Wurdack, Katharina
AU  - Grittner, Ulrike
AU  - Schilling, Ralph
AU  - Märschenz, Stefanie
AU  - Köbe, Theresa
AU  - Hofer, Sebastian J
AU  - Magnes, Christoph
AU  - Stekovic, Slaven
AU  - Eisenberg, Tobias
AU  - Sigrist, Stephan
AU  - Schmitz, Dietmar
AU  - Wirth, Miranka
AU  - Madeo, Frank
AU  - Flöel, Agnes
TI  - Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
JO  - JAMA network open
VL  - 5
IS  - 5
SN  - 2574-3805
CY  - Chicago, Ill.
PB  - American Medical Association
M1  - DZNE-2022-01137
SP  - e2213875
PY  - 2022
N1  - (CC BY)
AB  - Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one of the greatest challenges of our generation. Spermidine supplementation has shown beneficial effects on brain and cognitive health in animal models, and there has been preliminary evidence of memory improvement in individuals with subjective cognitive decline.To determine the effect of longer-term spermidine supplementation on memory performance and biomarkers in this at-risk group.This 12-month randomized, double-masked, placebo-controlled phase 2b trial (the SmartAge trial) was conducted between January 2017 and May 2020. The study was a monocenter trial carried out at an academic clinical research center in Germany. Eligible individuals were aged 60 to 90 years with subjective cognitive decline who were recruited from health care facilities as well as through advertisements in the general population. Data analysis was conducted between January and March 2021.One hundred participants were randomly assigned (1:1 ratio) to 12 months of dietary supplementation with either a spermidine-rich dietary supplement extracted from wheat germ (0.9 mg spermidine/d) or placebo (microcrystalline cellulose). Eighty-nine participants (89
KW  - Aged
KW  - Animals
KW  - Biomarkers
KW  - Cognition: physiology
KW  - Cognitive Dysfunction: drug therapy
KW  - Dietary Supplements
KW  - Female
KW  - Humans
KW  - Inflammation
KW  - Neurodegenerative Diseases
KW  - Spermidine: pharmacology
KW  - Spermidine: therapeutic use
KW  - Biomarkers (NLM Chemicals)
KW  - Spermidine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9136623
C6  - pmid:35616942
DO  - DOI:10.1001/jamanetworkopen.2022.13875
UR  - https://pub.dzne.de/record/164588
ER  -