Home > Publications Database > Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19 > print

001     164649
005     20240313115346.0
024 7 _ |a pmc:PMC9110324
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024 7 _ |a 10.1016/j.xcrm.2022.100652
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037 _ _ |a DZNE-2022-01179
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100 1 _ |a Frishberg, Amit
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245 _ _ |a Mature neutrophils and a NF-κB-to-IFN transition determine the unifying disease recovery dynamics in COVID-19
260 _ _ |a Maryland Heights, MO
|c 2022
|b Elsevier
336 7 _ |a article
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500 _ _ |a (CC BY-NC-ND)
520 _ _ |a Disease recovery dynamics are often difficult to assess, as patients display heterogeneous recovery courses. To model recovery dynamics, exemplified by severe COVID-19, we apply a computational scheme on longitudinally sampled blood transcriptomes, generating recovery states, which we then link to cellular and molecular mechanisms, presenting a framework for studying the kinetics of recovery compared with non-recovery over time and long-term effects of the disease. Specifically, a decrease in mature neutrophils is the strongest cellular effect during recovery, with direct implications on disease outcome. Furthermore, we present strong indications for global regulatory changes in gene programs, decoupled from cell compositional changes, including an early rise in T cell activation and differentiation, resulting in immune rebalancing between interferon and NF-κB activity and restoration of cell homeostasis. Overall, we present a clinically relevant computational framework for modeling disease recovery, paving the way for future studies of the recovery dynamics in other diseases and tissues.
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650 _ 7 |a COVID-19
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650 _ 7 |a cell deconvolution
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650 _ 7 |a disease modeling
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650 _ 7 |a disease recovery
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650 _ 7 |a gene regulation
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650 _ 7 |a immunology
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650 _ 7 |a medicine
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650 _ 7 |a systems biology
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650 _ 7 |a viral infection
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650 _ 7 |a NF-kappa B
|2 NLM Chemicals
650 _ 7 |a Interferons
|0 9008-11-1
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650 _ 2 |a COVID-19
|2 MeSH
650 _ 2 |a Cell Differentiation
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650 _ 2 |a Humans
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650 _ 2 |a Interferons: metabolism
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650 _ 2 |a NF-kappa B: genetics
|2 MeSH
650 _ 2 |a Neutrophils: metabolism
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650 _ 2 |a Signal Transduction
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700 1 _ |a Kooistra, Emma
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700 1 _ |a Nuesch-Germano, Melanie
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700 1 _ |a Pecht, Tal
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700 1 _ |a Milman, Neta
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700 1 _ |a Reusch, Nico
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700 1 _ |a Warnat-Herresthal, Stefanie
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700 1 _ |a Bruse, Niklas
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700 1 _ |a Händler, Kristian
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700 1 _ |a Theis, Heidi
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700 1 _ |a Kraut, Michael
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700 1 _ |a van Rijssen, Esther
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700 1 _ |a van Cranenbroek, Bram
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700 1 _ |a Koenen, Hans JPM.
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700 1 _ |a Heesakkers, Hidde
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700 1 _ |a van den Boogaard, Mark
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700 1 _ |a Zegers, Marieke
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700 1 _ |a Pickkers, Peter
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700 1 _ |a Becker, Matthias Kai Holger
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700 1 _ |a Aschenbrenner, Anna Christin
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700 1 _ |a Ulas, Thomas
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700 1 _ |a Theis, Fabian J.
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700 1 _ |a Shen-Orr, Shai S.
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700 1 _ |a Schultze, Joachim
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700 1 _ |a Kox, Matthijs
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773 _ _ |a 10.1016/j.xcrm.2022.100652
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