TY  - JOUR
AU  - Löhle, Matthias
AU  - Bremer, Alexander
AU  - Gandor, Florin
AU  - Timpka, Jonathan
AU  - Odin, Per
AU  - Ebersbach, Georg
AU  - Storch, Alexander
TI  - Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson’s disease
JO  - npj Parkinson's Disease
VL  - 8
SN  - 2373-8057
CY  - London [u.a.]
PB  - Nature Publ. Group
M1  - DZNE-2022-01181
SP  - 69
PY  - 2022
N1  - (CC BY)
AB  - The Parkinson’s disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen’s kappa) between patient and observer diary entries was 59.8
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC9163037
C6  - pmid:35654835
DO  - DOI:10.1038/s41531-022-00331-w
UR  - https://pub.dzne.de/record/164651
ER  -