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@ARTICLE{Lhle:164651,
      author       = {Löhle, Matthias and Bremer, Alexander and Gandor, Florin
                      and Timpka, Jonathan and Odin, Per and Ebersbach, Georg and
                      Storch, Alexander},
      title        = {{V}alidation of the {PD} home diary for assessment of motor
                      fluctuations in advanced {P}arkinson’s disease},
      journal      = {npj Parkinson's Disease},
      volume       = {8},
      issn         = {2373-8057},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DZNE-2022-01181},
      pages        = {69},
      year         = {2022},
      note         = {(CC BY)},
      abstract     = {The Parkinson’s disease (PD) home diary is frequently
                      used in clinical trials to measure efficacy of medical
                      treatments for motor fluctuations in advanced PD. This
                      prospective study in fluctuating PD patients examines the
                      validity of the diary for quantification of motor states in
                      comparison to direct clinical observation. 51 patients
                      (median age: 65 years, disease duration: 11 years) completed
                      the diary half-hourly for two consecutive days and were
                      simultaneously rated by an experienced observer, who
                      independently evaluated motor states half-hourly throughout
                      daytime. Overall agreement (Cohen’s kappa) between patient
                      and observer diary entries was $59.8\%$ (0.387). Patients
                      documented more On without dyskinesia $(52.3\%$ vs.
                      $38.9\%,$ P < 0.001) and less On with dyskinesia
                      $(21.5\%$ vs. $34.2\%,$ P < 0.001), whereas proportions
                      for Off intervals were not different between patient and
                      observer diaries $(26.2\%$ vs. $27.0\%,$ P = 0.97).
                      Temporal agreement between diary ratings was unsatisfactory,
                      particularly for On with dyskinesia. Taken together, our
                      study suggests that the PD home diary only inadequately
                      reflects actual motor states compared to direct clinical
                      observation.},
      cin          = {AG Teipel / AG Storch 2 Rostock},
      ddc          = {610},
      cid          = {I:(DE-2719)1510100 / I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC9163037},
      pubmed       = {pmid:35654835},
      doi          = {10.1038/s41531-022-00331-w},
      url          = {https://pub.dzne.de/record/164651},
}