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| 001 | 164651 | ||
| 005 | 20230915090555.0 | ||
| 024 | 7 | _ | |a pmc:PMC9163037 |2 pmc |
| 024 | 7 | _ | |a 10.1038/s41531-022-00331-w |2 doi |
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| 037 | _ | _ | |a DZNE-2022-01181 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Löhle, Matthias |0 P:(DE-2719)2813524 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson’s disease |
| 260 | _ | _ | |a London [u.a.] |c 2022 |b Nature Publ. Group |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 500 | _ | _ | |a (CC BY) |
| 520 | _ | _ | |a The Parkinson’s disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen’s kappa) between patient and observer diary entries was 59.8% (0.387). Patients documented more On without dyskinesia (52.3% vs. 38.9%, P < 0.001) and less On with dyskinesia (21.5% vs. 34.2%, P < 0.001), whereas proportions for Off intervals were not different between patient and observer diaries (26.2% vs. 27.0%, P = 0.97). Temporal agreement between diary ratings was unsatisfactory, particularly for On with dyskinesia. Taken together, our study suggests that the PD home diary only inadequately reflects actual motor states compared to direct clinical observation. |
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| 700 | 1 | _ | |a Bremer, Alexander |b 1 |
| 700 | 1 | _ | |a Gandor, Florin |0 0000-0003-2874-9817 |b 2 |
| 700 | 1 | _ | |a Timpka, Jonathan |0 0000-0002-2577-8607 |b 3 |
| 700 | 1 | _ | |a Odin, Per |b 4 |
| 700 | 1 | _ | |a Ebersbach, Georg |b 5 |
| 700 | 1 | _ | |a Storch, Alexander |0 P:(DE-2719)9000306 |b 6 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1038/s41531-022-00331-w |g Vol. 8, no. 1, p. 69 |0 PERI:(DE-600)2819218-7 |p 69 |t npj Parkinson's Disease |v 8 |y 2022 |x 2373-8057 |
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